dc.contributor.author | Bekircan, Olcay | |
dc.contributor.author | Küçük, Murat | |
dc.contributor.author | Kahveci, Bahittin | |
dc.contributor.author | Bektaş, Hakan | |
dc.date.accessioned | 2020-12-19T20:12:51Z | |
dc.date.available | 2020-12-19T20:12:51Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Bekircan, O., Küçük, M., Kahveci, B. & Bektaş, H. (2008). Synthesis and anticancer evaluation of some new 4-amino-3-(p-methoxybenzyl) -4,5-dihydro-1,2,4-triazole-5-one derivatives. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 63(11), 1305-1314. https://doi.org/10.1515/znb-2008-1109 | en_US |
dc.identifier.issn | 0932-0776 | |
dc.identifier.uri | https://doi.org/10.1515/znb-2008-1109 | |
dc.identifier.uri | https://hdl.handle.net/11436/3941 | |
dc.description.abstract | 4-Amino-3-p-methoxybenzyl-5-oxo-4,5-dihydro-1,2,4-triazol-1-yl-acetic acid ethyl ester (2) was prepared from 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-one (1) and ethyl bromoacetate. Compound 3 was synthesized by the condensation of 2 with hydrazine hydrate. The treatment of compound 3 with various aromatic aldehydes resulted in the formation of arylidene hydrazides as cis-trans conformers 4a-g. Thiosemicarbazide derivative 5 was prepared by the reaction of compound 3 with phenylisothiocyanate. Cyclization of 5 with sodium hydroxide resulted in the formation of compound 6. Treatment of 6 with benzyl bromide gave compound 7. Four of the newly synthesized compounds were screened for their anticancer activity against a panel of 60 cell lines derived from nine cancer types, namely, non-small cell lung, colon, breast, ovarian, leukemia, renal, melanoma, prostate and CNS cancers at a fixed dose of 10 ?M. © 2008 Verlag der Zeitschrift für Naturforschung. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Verlag der Zeitschrift fur Naturforschung | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | 1,2,4-Triazoles | en_US |
dc.subject | Anticancer activity | en_US |
dc.subject | Benzylidenehydrazides | en_US |
dc.subject | cis/trans amide conformers | en_US |
dc.subject | E/Z geometrical isomers | en_US |
dc.title | Synthesis and anticancer evaluation of some new 4-amino-3-(p-methoxybenzyl) -4,5-dihydro-1,2,4-triazole-5-one derivatives | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Kahveci, Bahittin | |
dc.identifier.doi | 10.1515/znb-2008-1109 | |
dc.identifier.volume | 63 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | 1305 | en_US |
dc.identifier.endpage | 1314 | en_US |
dc.relation.journal | Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |