dc.contributor.author | Işık, Pamir | |
dc.contributor.author | Yaralı, Neşe | |
dc.contributor.author | Tavil, Betül | |
dc.contributor.author | Demirel, Fatma | |
dc.contributor.author | Karaçam, Gülşah Bayram | |
dc.contributor.author | Saç, Rukiye Ünsal | |
dc.contributor.author | Fettah, Ali | |
dc.contributor.author | Özkasap, Serdar | |
dc.contributor.author | Kara, Abdurrahman | |
dc.contributor.author | Tunç, Bahattin | |
dc.date.accessioned | 2020-12-19T20:15:51Z | |
dc.date.available | 2020-12-19T20:15:51Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Isik, P., Yarali, N., Tavil, B., Demirel, F., Karacam, G. B., Sac, R. U., Fettah, A., Ozkasap, S., Kara, A., & Tunc, B. (2014). Endocrinopathies in Turkish children with Beta thalassemia major: results from a single center study. Pediatric hematology and oncology, 31(7), 607–615. https://doi.org/10.3109/08880018.2014.898724 | en_US |
dc.identifier.issn | 0888-0018 | |
dc.identifier.uri | https://doi.org/10.3109/08880018.2014.898724 | |
dc.identifier.uri | https://hdl.handle.net/11436/4051 | |
dc.description | PubMed: 24854890 | en_US |
dc.description.abstract | The endocrinological complications in ?-thalassemia major patients do affect the life quality to a large extend. In this study, the endocrinological complications of 47 ?-thalassemia patients, who have been followed-up at our hospital's pediatric hematology department, were evaluated. Out of ?-thalassemia major cases included to this study, the 55.3% was male and 44.7% was female. The patients' mean levels of ferritin, whose mean age was 10.0 ± 4.5 years (2-20 years), were 2497 ± 1469 ng/mL (472-8558 ng/mL). At least one endocrinological pathology in 27 out of 47 (57.4%) and more than one endocrinological pathology in 14 out of 47 (29.7%) thalassemia patients were observed. The most frequently observed complication in followed-up cases was vitamin D insufficiency and deficiency (78.2%). The other complications in decreasing order were pubertal failure (41.6%), growth retardation (25.5%), decreased bone-mineral density (22.2%), secondary hyperparathyroidism (11.5%), overt hypothyroidism (4.25%), subclinical hypothyroidism (2.12%), and impaired glucose tolerance (2.12%). There was no statistically significant difference between serum mean ferritin level and endocrin complications (P > .05). Four patients (8.5%) had decreased signal intensity in pituitary magnetic resonance imaging (MRI) but this finding was not associated with ferritin levels (P = .87). MRI parameters were similar between patients with and without gonadal dysfunction. Mean height of the pituitary gland was 4.98 ± 1.1 mm (3-9 mm) and this was similar to those normal values in the literature. Ferritin levels were not correlated with pituitary height (P > .05). Beta thalassemia major, having the potential of leading to multisystemic complications, is a chronic disease that should be treated and followed-up by a multidisciplinary approach. Due to frequently encountered endocrinological complications, beta thalassemic patients should be followed-up regularly by hematology and endocrinology departments in coordination. © 2014 Informa Healthcare USA, Inc. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Informa Healthcare | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Endocrinology | en_US |
dc.subject | Pediatrics | en_US |
dc.subject | Radiology | en_US |
dc.subject | Thalassemia | en_US |
dc.title | Endocrinopathies in Turkish children with beta thalassemia major: Results from a single center study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Özkasap, Serdar | |
dc.identifier.doi | 10.3109/08880018.2014.898724 | |
dc.identifier.volume | 31 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 607 | en_US |
dc.identifier.endpage | 615 | en_US |
dc.relation.journal | Pediatric Hematology and Oncology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |