dc.contributor.author | Güneş, Tevfik | |
dc.contributor.author | Bozok, Şahin | |
dc.contributor.author | Kestelli, Mert | |
dc.contributor.author | Yürekli, İsmail | |
dc.contributor.author | İlhan, Gökhan | |
dc.contributor.author | Özpak, Berkan | |
dc.contributor.author | Bademci, Mehmet | |
dc.contributor.author | Özcem, Barçın | |
dc.contributor.author | Şahin, Aykut | |
dc.date.accessioned | 2020-12-19T20:16:22Z | |
dc.date.available | 2020-12-19T20:16:22Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Gunes, T., Bozok, S., Kestelli, M., Yurekli, I., Ilhan, G., Ozpak, B., Bademci, M., Ozcem, B., & Sahin, A. (2012). α-tocopherol and ascorbic acid in early postoperative period of cardiopulmonary bypass. Journal of cardiovascular medicine (Hagerstown, Md.), 13(11), 691–699. https://doi.org/10.2459/JCM.0b013e328356a2dc | en_US |
dc.identifier.issn | 1558-2027 | |
dc.identifier.uri | https://doi.org/10.2459/JCM.0b013e328356a2dc | |
dc.identifier.uri | https://hdl.handle.net/11436/4185 | |
dc.description | PubMed: 22885531 | en_US |
dc.description.abstract | AIM: To investigate whether ?-tocopherol and ascorbic acid have effect on the suppression of inflammation in the early postoperative period after open heart surgery. METHODS: A total of 59 patients who had undergone cardiopulmonary bypass (CPB) in the Cardiovascular Surgery Department of a tertiary center between June 2008 and December 2008 were retrospectively investigated. The study group consisted of 34 patients (25 men, 9 women) to whom ascorbic acid (500mg/day) and ?-tocopherol (300mg/day) were administered on the day of operation (0th day) and the first four consecutive postoperative days. In contrast, 25 controls (20 men, 5 women) received no additional anti-inflammatory medications. The two groups were compared in terms of demographics, blood parameters such as C-reactive protein (CRP) and white blood cell (WBC) count, and durations of cross-clamp and CPB. RESULTS: In the control group, CRP levels were found to be increased on the first postoperative day (P<0.001) and CRP levels were correlated with triglyceride levels on the day of operation (P=0.009) and the first postoperative day (P=0.021). On the second postoperative day WBC count was found to be decreased (P=0.008) and correlated with glucose level (P<0.005). In the study group, CRP levels were found to be inversely correlated with serum high-density lipoprotein (HDL) (P=0.049) on the first postoperative day and directly correlated with triglyceride levels on the second postoperative day (P=0.017). Blood glucose levels were found to be increased on the first postoperative day (P=0.021) and a correlation was detected between WBC count on the fourth postoperative day and doses of ascorbic acid and ?-tocopherol (P=0.027). CONCLUSION: Suppression of the systemic inflammatory response to CPB is a double-edged sword and whether this suppression aids in the attenuation of morbidity and mortality is obscure. In this respect, ascorbic acid and ?-tocopherol seem to display some anti-inflammatory effect, but further studies are necessary to reveal the actual therapeutic potential and the complex mechanism related to biochemical and inflammatory parameters. © 2012 Italian Federation of Cardiology. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wolters Kluwer | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | α-Tocopherol | en_US |
dc.subject | Anti-inflammatory | en_US |
dc.subject | Ascorbic acid | en_US |
dc.subject | Open heart surgery | en_US |
dc.title | α-Tocopherol and ascorbic acid in early postoperative period of cardiopulmonary bypass | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Bozok, Şahin | |
dc.contributor.institutionauthor | İlhan, Gökhan | |
dc.identifier.doi | 10.2459/JCM.0b013e328356a2dc | |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | 691 | en_US |
dc.identifier.endpage | 699 | en_US |
dc.relation.journal | Journal of Cardiovascular Medicine | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |