dc.contributor.author | Mentese, A. | |
dc.contributor.author | Alver, A. | |
dc.contributor.author | Demir, S. | |
dc.contributor.author | Sumer, A. | |
dc.contributor.author | Yaman, O. | |
dc.contributor.author | Karkucak, M. | |
dc.contributor.author | Turan, I. | |
dc.date.accessioned | 2020-12-19T20:17:31Z | |
dc.date.available | 2020-12-19T20:17:31Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0303-464X | |
dc.identifier.uri | https://hdl.handle.net/11436/4401 | |
dc.description | PubMed: 28198796 | en_US |
dc.description.abstract | Background: Behçet's disease (BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase (CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjögren's syndrome, rheumatoid arthritis, endo metriosis, idiopathic chronic pancreatitis, type 1 diabe tes and Graves' disease. The goal of this study was to investigate CA I and II autoantibodies in BD. Methods: 35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA. Results: The CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p=0.013, p=0.0001, respectively). A cut-off value of 0.250 absorbance unit (ABSU) for anti-CA I was associated with 34% sensitivity and 100% specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54% sensitivity and 100% specificity for predicting BD. Conclusion: The CA I and II autoantibody levels in patients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of BD. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sociedade Portuguesa de Reumatologia | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Autoantibody | en_US |
dc.subject | Behçet's disease | en_US |
dc.subject | Carbonic anhydrase | en_US |
dc.title | Carbonic anhydrase i and ii autoantibodies in behçet's disease | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ | en_US |
dc.identifier.volume | 2017 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 26 | en_US |
dc.identifier.endpage | 31 | en_US |
dc.relation.journal | Acta Reumatologica Portuguesa | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |