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dc.contributor.authorKalyoncu, Şenol
dc.contributor.authorYılmaz, Bülent
dc.contributor.authorDemir, Mustafa
dc.contributor.authorTuncer, Meltem
dc.contributor.authorBozdağ, Zehra
dc.contributor.authorİnce, Onur
dc.contributor.authorBozdayı, Mehmet Akif
dc.contributor.authorUlusal, Hasan
dc.contributor.authorTaysi, Seyithan
dc.date.accessioned2020-12-19T20:22:44Z
dc.date.available2020-12-19T20:22:44Z
dc.date.issued2020
dc.identifier.citationKalyoncu, Ş., Yilmaz, B., Demir, M., Tuncer, M., Bozdağ, Z., Ince, O., Bozdayi, M. A., Ulusal, H., & Taysi, S. (2020). Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitrite. Turkish journal of medical sciences, 50(6), 1513–1522. https://doi.org/10.3906/sag-2004-135en_US
dc.identifier.issn1300-0144
dc.identifier.urihttps://doi.org/10.3906/sag-2004-135
dc.identifier.urihttps://hdl.handle.net/11436/4531
dc.descriptionPubMed: 32927928en_US
dc.description.abstractBackground/aim: To evaluate the protective effect of melatonin on ovarian ischemia reperfusion injury in a rat model. Materials and methods: Forty-eight rats were separated equally into 6 groups. Group 1: sham; Group 2: surgical control with 3-h bilateral ovarian torsion and detorsion; Group 3: intraperitoneal 5% ethanol (1 mL) just after detorsion (as melatonin was dissolved in ethanol); Group 4: 10 mg/kg intraperitoneal melatonin 30 min before 3-h torsion; Group 5:10 mg/kg intraperitoneal melatonin just after detorsion; Group 6:10 mg/kg intraperitoneal melatonin 30 min before torsion and just after detorsion. Both ovaries and blood samples were obtained 7 days after detorsion for histopathological and biochemical analysis. Results: In Group 1, serum levels of total oxidant status (TOS) (?mol H2 O2 equivalent/g wet tissue)were significantly lower than in Group2 (P = 0.0023), while tissue TOS levels were lower than in Group 3 (P = 0.0030). Similarly, serum and tissue levels of peroxynitrite in Group 6were significantly lower than those ofGroup 2 (P = 0.0023 and P = 0.040, respectively). Moreover, serum oxidative stress index (OSI) (arbitrary unit) levels were significantly increased in Group 2 when compared to groups 1 and 6 (P = 0.0023 and P= 0.0016, respectively) and in Group 3 with respect to groups 1, 4, 5, and 6 (P = 0.0023, P = 0.0026, P = 0.0008, and P = 0.0011, respectively). Furthermore, there was a significant decrease in histopathological scores including follicular degeneration, vascular congestion, hemorrhage, and inflammation in the melatonin and sham groups in comparison with control groups. Additionally, primordial follicle count was significantly higher in Group 6 than in Group 2 (P = 0.0002). Conclusion: Melatonin attenuates ischemia reperfusion damage in a rat torsion/detorsion model by improving histopathological and biochemical findings including OSI and peroxynitrite. © TÜBİTAK.en_US
dc.language.isoengen_US
dc.publisherTurkiye Kliniklerien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia reperfusion injuryen_US
dc.subjectMelatoninen_US
dc.subjectOxidative stress indexen_US
dc.subjectPeroxynitriteen_US
dc.subjectRat ovarian torsionen_US
dc.titleMelatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitriteen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorYılmaz, Bülent
dc.identifier.doi10.3906/sag-2004-135
dc.identifier.volume50en_US
dc.identifier.issue6en_US
dc.identifier.startpage1513en_US
dc.identifier.endpage1522en_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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