dc.contributor.author | Kocaman, Sinan Altan | |
dc.contributor.author | Baysan, Oben | |
dc.contributor.author | Çetin, Mustafa | |
dc.contributor.author | Altuner, Tuğba Kayhan | |
dc.contributor.author | Polat, Ezgi Ocaklı | |
dc.contributor.author | Durakoğlugil, Murtaza Emre | |
dc.contributor.author | Erdoğan, Turan | |
dc.contributor.author | Karaoğuz, Mustafa Remzi | |
dc.date.accessioned | 2020-12-19T20:42:30Z | |
dc.date.available | 2020-12-19T20:42:30Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Kocaman, S. A., Baysan, O., Çetin, M., Kayhan Altuner, T., Polat Ocaklı, E., Durakoğlugil, M. E., Erdoğan, T., & Karaoğuz, M. R. (2017). An increase in epicardial adipose tissue is strongly associated with carotid-intima media thickness and atherosclerotic plaque, but LDL only with the plaque. Anatolian journal of cardiology, 17(1), 56–63. https://doi.org/10.14744/AnatolJCardiol.2016.6885 | en_US |
dc.identifier.issn | 2149-2263 | |
dc.identifier.issn | 2149-2271 | |
dc.identifier.uri | https://app.trdizin.gov.tr/makale/TWpFM09EY3hNUT09 | |
dc.identifier.uri | https://hdl.handle.net/11436/5730 | |
dc.description.abstract | Objective: Carotid intima-media thickness (CIMT) is reliable marker of subclinical atherosclerosis and cardiovascular events. Until today, there was no study that investigated whether epicardial adipose tissue (EAT), which is a surrogate for lipid depot in a special visceral tissue or circulating lipids, is more important for CIMT and atherosclerotic plaque.Methods: Our study, having cross-sectional and prospective observational design, included 252 patients who were admitted to our outpatient clinic. EAT identified as an echo-free space under the pericardial layer on 2-dimensional echocardiography, was measured perpendicularly in front of the right ventricular free wall at end-systole.Results: EAT significantly correlated with CIMT (r=0.623, p<0.001). CIMT was significantly increased with rising EAT thickness (0.72±0.15 mm, 0.85±0.16 mm, and 0.95±0.12 mm in patients with EAT <5 mm, 5-7, and >7 mm, p<0.001, respectively). Multiple linear regression analysis revealed that age (Beta: 0.406, p<0.001), male gender (Beta: 0.244, p<0.001), and EAT (Beta: 0.450, p<0.001) as independent correlates of CIMT. Otherwise, in logistic regression analysis, only EAT (OR, 1.386; 95% CI, 1.203-1.597, p<0.001) and LDL cholesterol (OR, 1.013; 95% CI, 1.002-1.013, p=0.02) were independent predictors for presence of carotid plaque.Conclusion: Our study showed that EAT has a relationship with both CIMT and the presence of carotid plaque, but LDL is independently related to the plaque. This finding suggests that EAT thickness may be a risk factor and biomarker, playing an important role beginning from early stages of atherosclerosis, unlike LDL cholesterol, which appear to have a role in later stages of atherosclerosis. | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Kalp ve kalp damar sistemi | en_US |
dc.title | An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Durakoğlugil, Murtaza Emre | |
dc.contributor.institutionauthor | Erdoğan, Turan | |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 56 | en_US |
dc.identifier.endpage | 63 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | The Anatolian Journal of Cardiology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |