Histopathological and immunohistochemical evaluation of 84 uterine sarcomas according to current literature

Abstract

OBJECTIVE

It was aimed to reevaluate uterine sarcoma cases diagnosed in our institution within the last 20 years according to current information and to provide intra-departmental standardization in the differential diagnosis and reporting.

METHODS

Totally 84 uterine sarcoma cases were re-examined. Recurrence, metastasis, and prognostic data were collected from the patient files. Immunohistochemistry panel consisting of CD10, h-caldesmon, and cyclin D1 was applied to the representative tumor tissues. The relationships between the parameters studied were evaluated statistically.

RESULTS

Statistically significant differences were found between different histopathological types of uterine sar-comas (US) in terms of age distribution, tumor diameter, mitotic index, necrosis, depth of myometrial invasion, cervical, adnexial and/or omental involvement, lymphovascular invasion, lymph node metas-tasis, recurrence, and distant metastasis. Statistically significant correlation was determined between the prognosis of the patients and mitotic activity of their tumors and the presence of distant metastasis. The immunohistochemistry panel was found to have significant contribution to the histomorphological ex-amination in the differential diagnosis.

CONCLUSION

Routine use of CD10, h-caldesmon, and cyclin D1 in the histopathological evaluation of US and es-tablishing an updated standard checklist was thought to be beneficial for the differential diagnosis and reporting prognostic parameters.