dc.contributor.author | Akgün Çağlıyan, Gülsüm | |
dc.contributor.author | Hacıoğlu, Sibel | |
dc.contributor.author | Ünver Koluman, Sibel | |
dc.contributor.author | İlkkılıç, Kadir | |
dc.contributor.author | Nar, Rukiye | |
dc.contributor.author | Başer, Mehmet Nuri | |
dc.contributor.author | Bozdemir, Aslı | |
dc.contributor.author | Şenol, Hande | |
dc.contributor.author | Şen Türk, Nilay | |
dc.contributor.author | Erol, Veysel | |
dc.contributor.author | Yıldırım, Onurcan | |
dc.contributor.author | Çağlıyan, Ömer | |
dc.contributor.author | Güler, Nil | |
dc.date.accessioned | 2022-09-12T08:09:45Z | |
dc.date.available | 2022-09-12T08:09:45Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Akgün Çağlıyan, G., Hacıoğlu, S., Ünver Koluman, B., İlkkılıç, K., Nar, R., Başer, M. N., Bozdemir, A., Şenol, H., Şen Türk, N., Erol, V., Yılıdırım, O., Çağlıyan, Ö., & Güler, N. (2021). Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?. Turkish journal of medical sciences, 51(4), 2112–2119. https://doi.org/10.3906/sag-2101-406 | en_US |
dc.identifier.issn | 1300-0144 | |
dc.identifier.issn | 1303-6165 | |
dc.identifier.uri | https://doi.org/10.3906/sag-2101-406 | |
dc.identifier.uri | https://hdl.handle.net/11436/6436 | |
dc.description.abstract | Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1-190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high (>_ 2) or low (< 2) CONUT scores in terms of overall survival (OS) and progression-free survival (PFS). The 5-year OS and PFS in patients with high CONUT score was 52.1% and 49.7%. The 5-year OS and PFS in patients with low CONUT score was 79.8% and 75.6% (p < 0.001). In the multivariate analysis for OS, age >_ 65 years (HR = 1.80, p = 0.028), Eastern Cooperative Oncology Group (ECOG) > 1 (HR = 2.04, p = 0.006), stage IIIA-IVB disease (HR = 2.75, p = 0.001) and the CONUT score (HR = 1.15, p = 0.003) were found statistically significant. In the multivariate analysis for PFS, age >_ 65 years (HR = 2.02, p = 0.007), stage IIIA-IVB disease (HR = 2.42, p = 0.002) and the CONUT score (HR = 1.19, p = 0.001) were found to be significant parameters. Conclusion: High CONUT score reduces OS and PFS in DLBCL. CONUT score is an independent, strong prognostic index in patients with DLBCL. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TUBİTAK Scientific & Technical Research Council Turkey | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Lymphoma | en_US |
dc.subject | Controlling | en_US |
dc.subject | Nutritional Status score | en_US |
dc.subject | Survival | en_US |
dc.subject | Prognosis | en_US |
dc.title | Is CONUT score a prognostic index in patients with diffuse large cell lymphoma? | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | İlkkılıç, Kadir | |
dc.identifier.doi | 10.3906/sag-2101-406 | en_US |
dc.identifier.volume | 51 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 2112 | en_US |
dc.identifier.endpage | 2119 | en_US |
dc.relation.journal | Turkish Journal of Medical Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |