dc.contributor.author | Kalaycıoğlu, Ezgi | |
dc.contributor.author | Çetin, Mustafa | |
dc.contributor.author | Kiriş, Tuncay | |
dc.contributor.author | Özyıldız, Ali Gökhan | |
dc.date.accessioned | 2022-10-05T06:01:01Z | |
dc.date.available | 2022-10-05T06:01:01Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Kalaycıoğlu, E., Çetin, M., Kırış, T., & Özyıldız, A. G. (2021). Paradoxical association between lipoprotein cholesterol levels and left atrial function in hypertensive diabetic patients: A speckle tracking study. Journal of clinical ultrasound : JCU, 49(7), 667–673. https://doi.org/10.1002/jcu.23032 | en_US |
dc.identifier.issn | 0091-2751 | |
dc.identifier.issn | 1097-0096 | |
dc.identifier.uri | https://doi.org/10.1002/jcu.23032 | |
dc.identifier.uri | https://hdl.handle.net/11436/6654 | |
dc.description.abstract | Background Studies have shown that subclinical left atrial (LA) dysfunction can be diagnosed with two-dimensional speckle tracking echocardiography (2D-STE). Although low-density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular diseases, recent studies have reported a paradoxical relationship between LDL-C level and atrial fibrillation. In this study, we investigated the relationship between LDL-C levels and LA function.
Methods In 168 patients with the diagnosis of hypertension and diabetes, transthoracic echocardiography with LA 2D-STE was performed. The patients were then divided into two groups: normal LA-strain (n = 94) or impaired LA-strain (n = 74). The relationship between LDL-C and LA function was analyzed.
Results Patients with impaired LA-strain had higher body mass index (BMI) (p = 0.029), higher statin usage (p = 0.003), and lower LDL-C levels (p = 0.001) than patients with normal LA-strain. They also had lower left ventricle ejection fraction (LVEF) (p = 0.047) and higher E-wave velocity (mitral e, m/s) (p = 0.020). Multivariate logistic regression analysis showed that lower LDL-C (p = 0.034), higher BMI (p = 0.004), lower LVEF (p = 0.004), and higher E-wave velocity (p = 0.003) values were independently associated with impaired LA-strain. The area under the receiver operating curve of LDL-C in predicting impaired LA-strain was 0.645 (0.564-0.730, p < 0.05). LDL-C <= 112.5 mg/dl was found to be the optimal cut-off value with 74.5% sensitivity and 51.2% specificity in predicting impaired LA strain.
Conclusion In patients with hypertension and diabetes, LDC-C levels are moderately but independently and paradoxically associated with impaired LA function assessed by 2D-STE. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Left atrial mechanical function | en_US |
dc.subject | Left atrium | en_US |
dc.subject | Low-density lipoprotein cholesterol | en_US |
dc.subject | Two-dimensional speckle-tracking echocardiography | en_US |
dc.title | Paradoxical association between lipoprotein cholesterol levels and left atrial function in hypertensive diabetic patients: A speckle tracking study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Çetin, Mustafa | |
dc.contributor.institutionauthor | Özyıldız, Ali Gökhan | |
dc.identifier.doi | 10.1002/jcu.23032 | en_US |
dc.identifier.volume | 49 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 667 | en_US |
dc.identifier.endpage | 673 | en_US |
dc.relation.journal | Journal of Clinical Ultrasound | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |