dc.contributor.author | Eren, Gülnihan | |
dc.contributor.author | Kupik, Osman | |
dc.date.accessioned | 2022-10-26T08:25:49Z | |
dc.date.available | 2022-10-26T08:25:49Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Eren, G., & Kupik, O. (2022). Necrosis on pre-radiotherapy 18F-FDG PET/CT is a predictor for complete metabolic response in patients with non-small cell lung cancer. Medicine, 101(20), e29227. https://doi.org/10.1097/MD.0000000000029227 | en_US |
dc.identifier.isbn | 0025-7974 | |
dc.identifier.issn | 1536-5964 | |
dc.identifier.uri | https://doi.org/10.1097/MD.0000000000029227 | |
dc.identifier.uri | https://hdl.handle.net/11436/6843 | |
dc.description.abstract | To investigate necrosis on pre-radiotherapy (RT) F-18-FDG PET/CT (PETNECROSIS) as a predictor of complete metabolic response (CMR) in patients with non-small cell lung cancer (NSCLC). We evaluated patients with inoperable stage I-III NSCLC who underwent pre- and post-radiotherapy F-18-FDG PET/CT. The relationship between CMR and PETNECROSIS, SUVmax, gross tumor volume calculated with F-18-FDG PET/CT (GTV(PET-CT)), tumor size, histology, metabolic tumor volume (MTV), and RT dose was assessed using logistic regression analysis. To evaluate necrosis on F-18 FDG PET/CT, we drew a region of interest (ROI) in the area showing visually very low/or no fluorodeoxyglucose (FDG) uptake on PET images. If the SUVmax was lower than the blood pool SUVmax and showed significantly lower attenuation (10-30 Hounsfield units [HU]) from the surrounding tissue on non-intravenous contrast-enhanced low-dose correlative CT, we defined it as necrotic (PETNECROSIS). Fifty-three patients were included in this study. The mean age was 68.1 +/- 9.8 years. Twenty-one patients had adenocarcinoma, and 32 had squamous cell carcinoma. All parameters were independent of histologic status. Multivariate logistic regression analysis showed that SUVmax <= 11.6 vs >11.6, (P = .003; OR, 7.670, 95CI%: 2.013-29.231) and PETNECROSIS absence/presence were independent predictors for CMR (P = .028, OR: 6.704, 95CI% 1.214-30.394). The necrosis on F-18 FDG PET/CT and SUVmax > 11.6 could be an imaging marker for the complete metabolic response after definitive chemoradiotherapy or definitive RT alone in patients with NSCLC. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Fluorodeoxyglucose | en_US |
dc.subject | Necrosis | en_US |
dc.subject | Non-small cell lung cancer | en_US |
dc.subject | Positron emission tomography | en_US |
dc.subject | Radiotherapy | en_US |
dc.subject | Response | en_US |
dc.title | Necrosis on pre-radiotherapy F-18-FDG PET/CT is a predictor for complete metabolic response in patients with non-small cell lung cancer | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Eren, Gülnihan | |
dc.contributor.institutionauthor | Kupik, Osman | |
dc.identifier.doi | 10.1097/MD.0000000000029227 | en_US |
dc.identifier.volume | 101 | en_US |
dc.identifier.issue | 20 | en_US |
dc.identifier.startpage | e29227 | en_US |
dc.relation.journal | Medicine | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |