dc.contributor.author | Baltaş, Nimet | |
dc.date.accessioned | 2022-11-01T09:08:08Z | |
dc.date.available | 2022-11-01T09:08:08Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Baltaş N.(2022). Synthesis of quinazolinone derivatives containing an acyl hydrazone skeleton as potent anti-urease agents enzyme kinetic studies and anti-oxidant properties. Journal of Chemical Research, 46(3), 17475198221096568. https://doi.org/10.1177/174751982210965 | en_US |
dc.identifier.issn | 1747-5198 | |
dc.identifier.issn | 2047-6507 | |
dc.identifier.uri | https://doi.org/10.1177/174751982210965 | |
dc.identifier.uri | https://hdl.handle.net/11436/6874 | |
dc.description.abstract | This paper covers the synthesis, in vitro urease inhibition, enzyme kinetic parameters, and anti-oxidant studies of a novel series of quinazolinone derivatives containing an acyl hydrazone skeleton. Compounds 3a, 3b, 5a, and 5b, having IC50 values ranging from 1.86 +/- 0.07 to 6.38 +/- 0.11 mu g mL(-1), show greater inhibitory activity than the standard inhibitor, thiourea. Among the products, (2-[2-(3-methoxybenzyl)-4-oxoquinazolin-3(4H)-yl]acetohydrazide) proves to be the most potent, exhibiting enzyme inhibition activity with an IC50 value of 1.86 +/- 0.07 mu g mL(-1). Kinetic studies involving the Lineweaver-Burk plots reveal that the inhibition mechanism of the most active compounds (3a, 3b, 5a, and 5b) on urease activity are found to be in competitive mode. Also, the anti-oxidant activity and radical-scavenging properties of the synthesized compounds are evaluated using cupric reducing anti-oxidant activity, ferric reducing anti-oxidant capacity, 2,2 '-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid), and 2,2-diphenyl-1-picrylhydrazyl assays. Compounds 3a, b and 5a, b have good anti-oxidant properties and radical-scavenging activity at various final concentrations. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sage Publications | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acyl hydrazones | en_US |
dc.subject | Anti-oxidant activity | en_US |
dc.subject | Enzyme kinetics | en_US |
dc.subject | Quinazolinones | en_US |
dc.subject | Urease inhibition | en_US |
dc.title | Synthesis of quinazolinone derivatives containing an acyl hydrazone skeleton as potent anti-urease agents enzyme kinetic studies and anti-oxidant properties | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Baltaş, Nimet | |
dc.identifier.doi | 10.1177/17475198221096568 | en_US |
dc.identifier.volume | 46 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 17475198221096568 | en_US |
dc.relation.journal | Journal of Chemical Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |