dc.contributor.author | Şahin, Balkan | |
dc.contributor.author | Kanat, Ayhan | |
dc.contributor.author | Karadağ, Mehmet Kürşat | |
dc.contributor.author | Demirtaş, Rabia | |
dc.contributor.author | Aydın, Mehmet Dumlu | |
dc.date.accessioned | 2022-11-11T10:42:55Z | |
dc.date.available | 2022-11-11T10:42:55Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Sahin, B., Kanat, A., Karadag, M. K., Demirtas, R., & Aydin, M. D. (2022). Protective Felix Culpa Effect of Superior Sympathetic Cervical Ganglion Degenerations on Prevention of Basilar Artery Spasm After Subarachnoid Hemorrhage: A Preliminary Experimental Study. World neurosurgery, 164, e861–e867. https://doi.org/10.1016/j.wneu.2022.05.063 | en_US |
dc.identifier.issn | 1878-8750 | |
dc.identifier.issn | 1878-8769 | |
dc.identifier.uri | https://doi.org/10.1016/j.wneu.2022.05.063 | |
dc.identifier.uri | https://hdl.handle.net/11436/6985 | |
dc.description.abstract | BACKGROUND: Posterior cerebral blood flow is regulated by the basilar arteries (BAs). Vasospasm of BAs can occur after subarachnoid hemorrhage (SAH). Superior cervical sympathetic ganglia (SCG) fibers have a vasoconstrictor effect on the BA. We aimed to investigate the relationship between the degenerated neuron density of the SCG and the severity of BA vasospasm after experimental SAH.
METHODS: Twenty-four rabbits were used. Five were used as the control group, and 5 were used as the sham group. Experimental SAHs were performed in the remaining 14 animals (study group) by injecting homologous blood into the cisterna magna. After 3 weeks of injection, neuron densities of SCG and the severity of BA vasospasm index values (VSI) were examined histopathologically and compared statistically.
RESULTS: The mean VSI was 0.669 +/- 0.1129 in the control group, 0.981 +/- 0.159 in the sham group, and 1.512 +/- 0.298 in the study group. The mean degenerated neuronal density of SCG was 436 +/- 79/mm(3) in severe vasospasm (n = 3), 841 +/- 101/mm(3) in moderate vasospasm (n = 4), and 1.921 +/- 849/mm(3) in the less vasospasm detected animals (n = 6).
CONCLUSIONS: This study shows an inverse relationship between the degenerated neuronal density in the SCG and VSI values. This finding indicates a diminished sympathetic input from the SCG, resulting in a beneficial effect the felix culpa) by dilating the lumen diameter of the BA, so SCG degeneration after SAH protects the BA spasm. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Basilar arteries | en_US |
dc.subject | Degeneration | en_US |
dc.subject | Subarachnoid hemorrhage | en_US |
dc.subject | Superior cervical ganglion | en_US |
dc.subject | Vasospasm | en_US |
dc.title | Protective felix culpa effect of superior sympathetic cervical ganglion degenerations on prevention of basilar artery spasm after subarachnoid hemorrhage: A preliminary experimental study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Kanat, Ayhan | |
dc.identifier.doi | 10.1016/j.wneu.2022.05.063 | en_US |
dc.identifier.volume | 164 | en_US |
dc.identifier.startpage | E861 | en_US |
dc.identifier.endpage | E867 | en_US |
dc.relation.journal | World Neurosurgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |