Lipoprotein subfractions in patients with depression: The lipoprint system Lipoprotein sub-fractions and depression

Abstract

Aim: The aim of the study is to investigate the relationship between depression and changes in 25-OH Vitamin D and Lipoprotein serum levels, which have been suggested to be associated with Central Nervous System neurotransmission and certain psychiatric disorders.

Material and Methods: The study included a patient group consists of 40 depressive individuals who have applied to the Psychiatry outpatient clink of our hospital and have been first diagnosed with depression according to SCID-1 (Structured Clinical Interview for DSM IV Axis I Disorders) criteria and had no psychiatric or systemic disease that could affect the result, as well as a control group of 40 healthy individuals with similar demographic characteristics. In the collected serum samples. 25-OH vitamin D, LDL, HDL, VLDL, total cholesterol, and TG levels were measured enzymatically and spectrophotometrically: Apolipoprotein Al and Bl00 levels were measured nephelometrically, LDL and HDL subfractions were measured using the Upoprint System, and then the results were evaluated statistically.

Results: Atherogenic LDL 3 and LDL 4 were significantly higher In the patient group (p=0.001 and p=0.0155, respectively). The mean LDL particle diameter (LDL Mean) was significantly lower in the patient group (13-0.0017). There was no significant difference between the patient and control groups in terms of Buoyant LDL, but Small Dense LDL levels were significantly higher in the patient group (p=0.008 and p<0.001, respectively). LDL 1 Subfraction level of the patient group was statistically significantly higher than the control group (p 0.0046). There was no significant difference in LDL 2 (p=0.3560).

Discussion: According to the results, LDL 3, LDL 4, and Small Dense LDL serum levels of the patients with depression were found to be higher. The fact that Small Dense LDL has a long circulation time in the blood, atherogenic and proinflammatory properties, better penetrability into the arterial intima layer and is considered as a risk factor in the CVD group, suggests that the risk of atherosclerosis, inflammation and CVD may be higher in patients with depression.