dc.contributor.author | Tok, Fatih | |
dc.contributor.author | Küçükal, Bahar | |
dc.contributor.author | Baltaş, Nimet | |
dc.contributor.author | Tatar Yılmaz, Gizem | |
dc.contributor.author | Koçyiğit Kaymakçıoğlu, Bedia | |
dc.date.accessioned | 2022-11-18T11:58:51Z | |
dc.date.available | 2022-11-18T11:58:51Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Tok, F., Kucukal, B., Baltas, N., Yilmaz, G.T. & Kocyigit Kaymakcioglu, B. (2022). Synthesis of novel thiosemicarbazone derivatives as antidiabetic agent with enzyme kinetic studies and antioxidant activity. Phosphorus, Sulfur, and Silicon and the Related Elements. https://doi.org/10.1080/10426507.2022.2099857 | en_US |
dc.identifier.issn | 1042-6507 | |
dc.identifier.issn | 1563-5325 | |
dc.identifier.uri | https://doi.org/10.1080/10426507.2022.2099857 | |
dc.identifier.uri | https://hdl.handle.net/11436/7065 | |
dc.description.abstract | Novel thiosemicarbazone derivatives were synthesized via condensation reactions between the corresponding thiosemicarbazides and 4-(methylsulfonyl)acetophenone. The chemical structures of all compounds were elucidated by infrared (IR), H-1-NMR and C-13-NMR spectroscopy and mass spectrometry. Antioxidant studies of all compounds were performed by using CUPRAC, FRAP, DPPH methods. 2-{1-[4-(Methylsulfonyl)phenyl]ethylidene}-N-phenylhydrazinecarbothioamide (1) possessed good antioxidant activity with an SC50 value of 15.70 mu M which also is higher than standard drug, ascorbic acid. All compounds were evaluated for their antidiabetic properties as alpha-glycosidase and alpha-amylase inhibitors. Compound 1 was found to be the most active compound against alpha-glucosidase and alpha-amylase with IC50 values of 1.58 mu M and 3.24 mu M, respectively. The enzyme kinetic studies demonstrated that compound 1 has a competitive mode of binding. Furthermore, molecular docking studies have elucidated the binding mechanism at the molecular level by examining the molecular interactions between compound 1 and these enzymes. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd. | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Thiosemicarbazones | en_US |
dc.subject | Alpha-glucosidase | en_US |
dc.subject | Alpha-amylase | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Molecular docking | en_US |
dc.title | Synthesis of novel thiosemicarbazone derivatives as antidiabetic agent with enzyme kinetic studies and antioxidant activity | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Küçükal, Bahar | |
dc.contributor.institutionauthor | Baltaş, Nimet | |
dc.identifier.doi | 10.1080/10426507.2022.2099857 | en_US |
dc.relation.journal | Phosphorus, Sulfur, and Silicon and the Related Elements | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |