dc.contributor.author | Cebeci, Yıldız Uygun | |
dc.contributor.author | Ceylan, Şule | |
dc.contributor.author | Karaoğlu, Şengül Alpay | |
dc.contributor.author | Altun, Muhammed | |
dc.date.accessioned | 2022-11-19T12:33:10Z | |
dc.date.available | 2022-11-19T12:33:10Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Cebeci, Y. U., Ceylan, Ş., Karaoğlu, Ş. A., & Altun, M. (2022). An efficient microwave-assisted synthesis of novel quinolone-triazole and conazole-triazole hybrid derivatives as antimicrobial and anticancer agents. Journal of Heterocyclic Chemistry. https://doi.org/10.1002/jhet.4560 | en_US |
dc.identifier.issn | 0022-152X | |
dc.identifier.issn | 1943-5193 | |
dc.identifier.uri | https://doi.org/10.1002/jhet.4560 | |
dc.identifier.uri | https://hdl.handle.net/11436/7066 | |
dc.description.abstract | 1,2,4-Triazole-fluoroquinolone and 1,2,4-triazole-conazole hybrids are designed, synthesized, and investigated in vitro against a variety of common diseases. The structure of the newly synthesized compounds are characterized from spectral data (IR, H-1 NMR, C-13 NMR, and LC-MS). The antibacterial activity against both Gram-positive and Gram-negative bacteria is shown to be enhanced by many of the produced compounds. Also, some of the products are found to have strong antiproliferative effects aganist HeLa cervical cancer cells, whilst demonstrating cytotoxic effects toward normal cells. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antibacterial activity | en_US |
dc.subject | DNA gyrase | en_US |
dc.subject | Inhibitors | en_US |
dc.title | An efficient microwave-assisted synthesis of novel quinolone-triazole and conazole-triazole hybrid derivatives as antimicrobial and anticancer agents | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Karaoğlu, Şengül Alpay | |
dc.identifier.doi | 10.1002/jhet.4560 | en_US |
dc.relation.journal | Journal of Heterocyclic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |