dc.contributor.author | Kaya Kantar, Günay | |
dc.date.accessioned | 2022-12-12T08:31:51Z | |
dc.date.available | 2022-12-12T08:31:51Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Kaya, Kantar, G. (2021). Novel fumarate derivatives synthesis and investigation of acetylcholinesterase inhibitor properties. El-Cezeri Journal of Science and Engineering, 8(2), 544-551. https://doi.org/10.31202/ecjse.819956 | en_US |
dc.identifier.issn | 2148-3736 | |
dc.identifier.uri | https://doi.org/10.31202/ecjse.819956 | |
dc.identifier.uri | https://hdl.handle.net/11436/7267 | |
dc.description.abstract | In this study, new fumarate compounds (I-IV) containing some natural phenols (eugenol, guaiacol, isoeugenol and vanillin) were synthesized and characterized. The single crystal X-ray diffraction technique was used to determine the crystal structures of all compounds. All compounds were evaluated as acetylcholinesterase (AChE) inhibitory, especially compound IV (IC50 = 5.25±0.51 µg/mL), can be identified as a promising anti-acetylcholinesterase agent due to its good inhibitory effect, when compared with donepezil hydrochloride (IC50 =16.02±0.66 µg/mL) as used standard acetylcholinesterase inhibitory agent. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TUBİTAK Scientific & Technical Research Council Turkey | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acetylcholinesterase inhibition | en_US |
dc.subject | Fumarate compound | en_US |
dc.subject | X-ray | en_US |
dc.title | Novel fumarate derivatives synthesis and investigation of acetylcholinesterase inhibitor properties | en_US |
dc.title.alternative | Yeni fumarat türevlerinin sentezi ve asetilkolinesteraz inhibitörü etkilerinin araştırılması | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Kaya Kantar, Günay | |
dc.identifier.doi | 10.31202/ecjse.819956 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 544 | en_US |
dc.identifier.endpage | 551 | en_US |
dc.relation.journal | El-Cezeri Journal of Science and Engineering | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |