Synthesis of Benzimidazole derivatives containing Schiff base exhibiting antiurease activities
Citation
Akyuz, G. (2021). Synthesis of Benzimidazole derivatives containing Schiff base exhibiting antiurease activities. Cumhuriyet Science Journal, 4283), 649-655. https://doi.org/10.17776/csj.867783Abstract
In this study some novel Schiff bases derivatives of benzimidazole containing thiophene ring
were designed and synthesized by using various aldehydes. Seven different aromatic
aldehydes with various side groups were used for synthesized. 1
H-NMR, 13C-NMR spectra
and LC-MS were used to identify all of the compounds. All synthesized compounds anti urease
activities were calculated according to phenol-hypochlorite method by Weatherburn. The
results indicated that all compounds have anti urease activity between 12.70±0.11 µg/mL and
14.00±0.08 µg/mL IC50 values. Especially the compound N'-[(1E)-2-furylmethylene]-2-[5,6-
dimethyl-2-(2-thienylmethyl)-1H-benzimidazol-1-yl]acetohydrazide (5g) has very close IC50
value (12.70±0.11 µg/mL) to thiourea (12.60±0.10 µg/mL) that is the standard inhibitor. 5g
bearing furan ring at the N-3 position on the benzimidazole nucleus has the smallest volume
of side group than others.