dc.contributor.author | Tüfekçi, Damla | |
dc.contributor.author | Ayaz, Teslime | |
dc.contributor.author | Şahin, Serap Baydur | |
dc.contributor.author | Hocaoğlu, Çiçek | |
dc.date.accessioned | 2023-08-15T05:50:21Z | |
dc.date.available | 2023-08-15T05:50:21Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Tufekci, D., Ayaz, T., Sahin, S. B., & Hocaoglu, C. (2023). The "Non-Treated" Versus "LT3-Treated" Protocols of Short-Term Hypothyroidism Induction in Differentiated Thyroid Cancer: An Analysis of Hypothyroid Complications, Mood Disorders, and Quality of Life. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 55(7), 462–470. https://doi.org/10.1055/a-2056-6073 | en_US |
dc.identifier.issn | 0018-5043 | |
dc.identifier.issn | 1439-4286 | |
dc.identifier.uri | https://doi.org/10.1055/a-2056-6073 | |
dc.identifier.uri | https://hdl.handle.net/11436/7992 | |
dc.description.abstract | This study aimed to compare "non-treated" versus "levotriiodothyronine (LT3)-treated" protocols of short-term hypothyroidism induction prior to radioactive iodine (RAI) ablation therapy in differentiated thyroid cancer (DTC). A total of 120 DTC patients who had thyroxine withdrawal either via 4-week hypothyroidism induction (non-treated group, n=60) or 2-week administration and then 2-week withdrawal of LT3 (LT3-treated group, n=60) to induce hypothyroid state prior to RAI ablation after initial surgery were included. Complications related to hypothyroidism-induction, Beck Depression Inventory (BDI), Hospital Anxiety-Depression Scale (HADS), and SF-36 health-related quality of life (HRQoL) scores were recorded. In the non-treated group, transition from euthyroid to hypothyroid state was associated with significant increase in the likelihood of moderate-to-severe depression on BDI (p<0.001), presence of depression on HADS-D (p<0.001), presence of anxiety on HADS-A (6.7% during euthyroid state vs. 33.3% during hypothyroid state, p<0.001), and major syndrome on BPRS (0.0 vs. 10.0%, p=0.001) as well as significant decrease in all SF-36 HRQoL domain scores (p<0.001 for each). In conclusion, our findings indicate the likelihood of L3-treatment to enable a more favorable transition period from euthyroid to hypothyroid state without experiencing a deterioration in depression, anxiety, or HRQoL. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Georg Thieme Verlag | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Differentiated thyroid carcinoma | en_US |
dc.subject | Hypothyroidism induction | en_US |
dc.subject | LT3-protocol | en_US |
dc.subject | Depression | en_US |
dc.subject | Anxiety | en_US |
dc.subject | Quality of life | en_US |
dc.title | The "non-treated" versus "LT3-treated" protocols of short-term hypothyroidism induction in differentiated thyroid cancer: an analysis of hypothyroid complications, mood disorders, and quality of life | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Tüfekçi, Damla | |
dc.contributor.institutionauthor | Ayaz, Teslime | |
dc.contributor.institutionauthor | Hocaoğlu, Çiçek | |
dc.identifier.doi | 10.1055/a-2056-6073 | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 07 | en_US |
dc.identifier.startpage | 462 | en_US |
dc.identifier.endpage | 470 | en_US |
dc.relation.journal | Hormone and Metabolic Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |