dc.contributor.author | Devrimsel, Gül | |
dc.contributor.author | Arpa, Medeni | |
dc.contributor.author | Beyazal, Münevver Serdaroğlu | |
dc.date.accessioned | 2023-08-18T07:26:00Z | |
dc.date.available | 2023-08-18T07:26:00Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Devrimsel, G., Arpa, M. & Beyazal, M.S. (2023). Relationship between galectin-3 level and disease activity in ankylosing spondylitis patients. Egyptian Rheumatology and Rehabilitation, 50(1), 28. https://doi.org/10.1186/s43166-023-00196-8 | en_US |
dc.identifier.issn | 1110-161X | |
dc.identifier.issn | 2090-3235 | |
dc.identifier.uri | https://doi.org/10.1186/s43166-023-00196-8 | |
dc.identifier.uri | https://hdl.handle.net/11436/8063 | |
dc.description.abstract | Background and aimsAnkylosing spondylitis (AS) is a chronic inflammatory disease that chiefly affects the sacroiliac joints and the spine. Galectin-3, a chimera-type member of the galectin family, binds glycoconjugates containing N-acetyllactosamine. Galectins play a role in regulation of embryogenesis, angiogenesis, neurogenesis, and immunity. The aim of the present study was to evaluate the serum galectin-3 level and its possible association with disease activity in AS patients. Forty five AS patients and 35 healthy controls enrolled in this study. All participants with a history of hyperlipidemia, liver, renal, hematological, familial thyroid, neoplastic, autoimmune infectious diseases and using anti-inflammatory drugs were excluded from the study. Serum galectin-3 levels concentration was measured using a commercial chemiluminescent microparticle immunoassay. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were measured. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score-CRP (ASDAS-CRP) were used to evaluate disease activity in AS patients.ResultsSerum galectin-3 levels were significantly higher in AS patients compared to the control group (p = 0.04). A correlation was determined between the serum galectin-3 levels and BASDAI and ASDAS-CRP scores in the AS patients (r = 0.49, p < 0.001; r = 0.56, p < 0.001, respectively). In AS patients, serum galectin-3 levels were significantly related with CRP levels but were not related with ESR (r = 0.57, p < 0.001; r = 0.25, p = 0.09, respectively).ConclusionsThe serum galectin-3 levels were higher in AS patients and were correlated with disease activity. This study may be useful to reveal the role of galectin-3 in inflammation and to evaluate disease activity in AS patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Ankylosing spondylitis | en_US |
dc.subject | Disease activity | en_US |
dc.subject | Galectin-3 | en_US |
dc.subject | Inflammation | en_US |
dc.title | Relationship between galectin-3 level and disease activity in ankylosing spondylitis patients | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Devrimsel, Gül | |
dc.contributor.institutionauthor | Arpa, Medeni | |
dc.contributor.institutionauthor | Beyazal, Münevver Serdaroğlu | |
dc.identifier.doi | 10.1186/s43166-023-00196-8 | en_US |
dc.identifier.volume | 50 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 28 | en_US |
dc.relation.journal | Egyptian Rheumatology and Rehabilitation | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |