dc.contributor.author | Kantar, Günay Kaya | |
dc.contributor.author | Baltaş, Nimet | |
dc.contributor.author | Şahin, Onur | |
dc.contributor.author | Şaşmaz, Selami | |
dc.date.accessioned | 2023-08-22T06:26:06Z | |
dc.date.available | 2023-08-22T06:26:06Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Kantar, G.K., Baltaş, N., Şahin, O. & Şaşmaz, S. (2023). a-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin. Indian Journal of Chemistry, 62(7), 728-734. https://doi.org/10.56042/ijc.v62i7.3730 | en_US |
dc.identifier.issn | 0019-5103 | |
dc.identifier.uri | https://doi.org/10.56042/ijc.v62i7.3730 | |
dc.identifier.uri | https://hdl.handle.net/11436/8093 | |
dc.description.abstract | Vanillin substituted novel zinc(II) azaphthalocyanines (ZnAzaPcs) have been synthesized and investigated for their & alpha;-glucosidase inhibition properties. The new compounds (1, 2, 1a and 2a) have been characterised using a combination of FT-IR, 1H and 13C NMR, UV-Vis, MS and elemental analysis. The crystal structures of starting pyrazine compounds 1 and 2 have also been determined by the single crystal diffraction technique. All newly synthesized compounds have been evaluated for their in vitro inhibitory activity against a-glucosidase and all of them have more inhibitory effect when compared to acarbose as reference compound. Especially, compound 2 shows the most significant a-glucosidase inhibition. IC50 values of compound 2 and acarbose, which is known as & alpha;-glucosidase inhibitor used as anti-diabetic drug, have been found to be 6.01 & PLUSMN;0.16 and 9.52 & PLUSMN;0.23 & mu;g/mL, respectively. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Natl Inst Science Communication & Policy Research | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Azaphthalocyanine | en_US |
dc.subject | Vanillin | en_US |
dc.subject | a-Glucosidase inhibition | en_US |
dc.title | a-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Kantar, Günay Kaya | |
dc.contributor.institutionauthor | Baltaş, Nimet | |
dc.contributor.institutionauthor | Şaşmaz, Selami | |
dc.identifier.doi | 10.56042/ijc.v62i7.3730 | en_US |
dc.identifier.volume | 62 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 728 | en_US |
dc.identifier.endpage | 734 | en_US |
dc.relation.journal | Indian Journal of Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |