dc.contributor.author | Akyüz, Gülay | |
dc.contributor.author | Menteşe, Emre | |
dc.date.accessioned | 2023-09-12T10:39:21Z | |
dc.date.available | 2023-09-12T10:39:21Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Akyüz, G. & Menteşe, E. (2023). Synthesis of New Coumarin-C-3 Benzimidazole Hybrids and Their Urease Inhibition Studies. Letters in Organic Chemistry, 20(9), 864-870. http://doi.org/10.2174/1570178620666230418113901 | en_US |
dc.identifier.issn | 1570-1786 | |
dc.identifier.issn | 1875-6255 | |
dc.identifier.uri | http://doi.org/10.2174/1570178620666230418113901 | |
dc.identifier.uri | https://hdl.handle.net/11436/8296 | |
dc.description.abstract | A novel series of coumarin-benzimidazole hybrids were designed, synthesized, and extensively characterized using spectral data, including FT-IR, H-1-NMR, and C-13-NMR. Weatherburn's method was used to test new compounds' inhibition of urease activity. The results were evaluated by considering the effects of different side groups and hybridization. The chlorine atom in the molecules notably affects the inhibitory activity of urease. The best result was obtained with the compound "6-chloro-N'-{[5,6-dichloro-2-(2-thienylmethyl)-1H-benzimidazol-1-yl]acetyl}-2-oxo-2H-chromene-3-carbohydrazide" (3b) with IC50= 12.48 & PLUSMN;0.12 & mu;g/mL against Jack bean urease. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Bentham Science Publications | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Hybridization | en_US |
dc.subject | Coumarin-benzimidazole hybrids | en_US |
dc.subject | Chlorine atom | en_US |
dc.subject | Urease activity | en_US |
dc.subject | Weatherburn's method | en_US |
dc.subject | Fused hybrids | en_US |
dc.title | Synthesis of new coumarin-C-3 benzimidazole hybrids and their urease inhibition studies | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Akyüz, Gülay | |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.identifier.doi | 10.2174/1570178620666230418113901 | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 864 | en_US |
dc.identifier.endpage | 870 | en_US |
dc.relation.journal | Letters in Organic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |