Kurum Yazarı "Mercantepe, Tolga" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
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The effects of dexmedetomidine on abdominal aortic occlusion-induced ovarian injury via oxidative stress and apoptosis
Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Akyıldız, Kerimali; Çiftel, Serpil; Yılmaz, Adnan (Karger, 2023)Ischemia/reperfusion (IR) induced ovarian damage is caused by various diseases such as ovarian torsion, ovarian transplantation, cardiovascular surgery, sepsis, or intra-abdominal surgery. I/R-related oxidative damage can ... -
The effects of dexmedetomidine on early acute kidney injury in severely burned rats
Özdemir, Ayşe; Topçu, Atilla; Mercantepe, Tolga; Arpa, Medeni; Karakaş, Sibel Mataracı; Özdemir, Ali Sezin; Tümkaya, Levent; Mercantepe, Filiz (Verduci Publisher, 2023)OBJECTIVE: Burns are a global medical and economic problem. In addition to high costs, the lengthy therapeutic process and the emotional trauma experienced by patients and their families indirectly worsen the socioeconomic ... -
The effects of dexmedetomidine on trauma-induced secondary injury in rat brain
Şen, Ahmet; Erdivanlı, Başar; Tümkaya, Levent; Uydu, Hüseyin Avni; Mercantepe, Tolga; Batçık, Şule; Özdemir, Abdullah (Taylor & Francis Ltd., 2023)Background: The objective of this study was to investigate the effect of dexmedetomidine (Dex), a sedative drug with little or no depressant effect on respiratory centers, on secondary injury in rat brain tissue by means ... -
Effects of gadodiamide and gadoteric acid on lung tissue: A comparative study
Çeliker, Fatma Beyazal; Tümkaya, Levent; Suzan, Zehra T.; Topçu, Atilla; Mercantepe, Tolga; Çınar, Seda; Yazıcı, Zihni Açar; Yılmaz, Adnan (Wiley, 2022)We set out to investigate the effects of gadodiamide and gadoteric acid, used for magnetic resonance imaging, on the lungs. In this study, 32 male Sprague Dawley rats were used. These were allocated into four groups; The ... -
Effects of gadodiamide and gadoteric acid on rat kidneys: A comparative study
Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Beyazal, Mehmet; Turan, Arzu; Beyazal Polat, Hatice; Suzan, Zehra Topal; İnecikli, Mehmet Fatih; Akyıldız, Kerimali; Yılmaz, Adnan (Wiley, 2019)Background Gadolinium-based contrast agents are complex chelates to provide contrast in NRI. However, recent studies have highlighted the deposition of free Gd+3 ion in various tissues. Purpose To evaluate the histopathological ... -
Effects of gadolinium-based contrast agents on submandibular gland tissue in rats
Çeliker, Fatma Beyazal; Tümkaya, Levent; Yılmaz, Adnan; Coşkun, Zerrin Özergin; Çeliker, Metin; Oğhan, Fatih; Mercantepe, Tolga; Terzi, Suat; Dursun, Engin (Springer, 2018)The aim of this prospective animal study is to investigate the influence of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCA) on ... -
Effects of gadolinium-based MRI contrast agents on liver tissue
Mercantepe, Tolga; Tümkaya, Levent; Çeliker, Fatma Beyazal; Suzan, Zehra Topal; Çınar, Seda; Akyıldız, Kerimali; Mercantepe, Filiz; Yılmaz, Adnan (Wiley, 2018)BackgroundPurposeMRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium-based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models. ... -
Effects of infliximab against carbon tetrachloride-induced intestinal injury via lipid peroxidation and apoptosis
Pergel, Ahmet; Tümkaya, Levent; Çolakoğlu, Muhammed Kadri; Demiral, Gökhan; Kalcan, Süleyman; Özdemir, Ali; Mercantepe, Tolga; Yılmaz, Adnan (Sage Publications Ltd, 2019)Carbon tetrachloride (CCL4) is often employed in the production of chlorofluorocarbons, petroleum refining, oil and rubber processing, and laboratory applications. Oral, subcutaneous, and inhalation exposure to CCL4 in ... -
Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats
Bahçeci, İlkay; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, H.; İbik, Y.E.; Duran, Ömer Faruk; Arslan, Nurgül (Verduci Publisher, 2023)OBJECTIVE: Carbon tetrachloride (CCl4 ) is a non-polar molecule used in industry in grain curing, insect-killing and especially in the production of chlorofluorocarbons. It is estimated that an average of 70,000 industry ... -
Effects of infliximab against methotrexate toxicity in splenic tissue via the regulation of CD3, CD68, and C200R in rats
Mercantepe, Tolga; Tümkaya, Levent; Mercantepe, Filiz (Karger, 2018)Methotrexate (MTX), which has been used in clinical practice for approximately 70 years, is still widely employed in the treatment of rheumatoid arthritis (RA), psoriasis, and cancer. Although MTX toxicity causes nephrotoxicity, ... -
The effects of long-term doppler ultrasound exposure in the prenatal period on renal tissue physiology in rats
Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Zengin, Ertan; Beyazal, Mehmet; Turan, Arzu; Polat, Hatice Beyazal; Suzan, Zehra Topal; Yılmaz, Adnan (Taylor & Francis Inc., 2022)Doppler ultrasonography (DUSG) is widely used for fetal evaluations. This study investigated the effects of new generation Doppler ultrasound application at different frequencies during pregnancy on postnatal renal ... -
Effects of long-term Doppler ultrasound exposure on cochlea and cochlear nucleus in prenatal period in an experimental model
Çeliker, Metin; Beyazal Çeliker, Fatma; Tümkaya, Levent; Oğhan, Fatih; Özgür, Abdulkadir; Mercantepe, Tolga; Terzi, Suat; Beyazal, Mehmet; Turan, Arzu; Çınar, Seda; Zengin, Ertan; Demir, Emine; Dursun, Engin (Taylor & Francis Ltd., 2021)Background New generation Doppler ultrasonography (DUSG) application effects on cochlea and cochlear nucleus (CN) are unclear. We aimed to investigate the effects of new generation DUSG application at different frequencies ... -
Effects of long-term exposure to 900 megahertz electromagnetic field on heart morphology and biochemistry of male adolescent rats
Kerimoğlu, Gökçen; Mercantepe, Tolga; Erol, Hüseyin Serkan; Turgut, Alpgiray; Kaya, Haydar; Çolakoğlu, Serdar; Odacı, Ersan (Taylor & Francis Ltd, 2016)The pathological effects of exposure to an electromagnetic field (EMF) during adolescence may be greater than those in adulthood. We investigated the effects of exposure to 900 MHz EMF during adolescence on male adult rats. ... -
Effects of mineral trioxide aggregate and methyl sulfonyl methane on pulp exposure via RUNX2 and RANKL pathways
Ateş, Altar; Kurt, Ayça; Mercantepe, Tolga (Springer Link, 2024)The aim of this study was to determine the therapeutic effects of mineral trioxide aggregate (MTA) and methyl sulfonyl methane (MSM) on pulp damage due to pulp exposure through the RUNX2 and RANKL pathways. Seventy-two ... -
Effects of ozone pretreatment on viability of random pattern skin flaps in rats
Öksüz, Mustafa; Yüce, Serdar; Koçak, Ömer Faruk; Canbaz, Yasin; Rağbetli, Murat Çetin; Mercantepe, Tolga (Taylor and Francis Ltd, 2015)Background: Medical ozone is a chemical agent that consists of three oxygen atoms and has antioxidant, angiogenic and vasodilator effects. This study evaluated the effects of medical ozone pre-treatment on flap survival. ... -
The effects of prenatal exposure to a 900-MHz electromagnetic field on the 21-day-old male rat heart
Türedi, Sibel; Hancı, Hatice; Topal, Zehra; Ünal, Deniz; Mercantepe, Tolga; Bozkurt, İlyas; Kaya, Haydar; Odacı, Ersan (Taylor & Francis Inc, 2015)The growing spread of mobile phone use is raising concerns about the effect on human health of the electromagnetic field (EMF) these devices emit. the purpose of this study was to investigate the effects on rat pup heart ... -
The effects of TNF-alpha inhibitors on carbon tetrachloride-induced nephrotoxicity
Özdemir, Ali; Tümkaya, Levent; Kalcan, Süleyman; Uyan, Mikail; Karakaya, Ahmet; Demiral, Gökhan; Samancı, Tuğba Çelik; Mercantepe, Tolga; Cüre, Medine Cumhur; Cüre, Erkan (Taylo & Francis Ltd., 2021)Objectives: Carbon tetrachloride (CCl4), employed in various industrial fields, can cause acute damage in renal tissues. This study investigated the therapeutic effect of the TNF-alpha inhibitor Infliximab on TGF-beta and ... -
Evaluation of the protective effect of coenzyme Q10 against x-ray irradiation-induced ovarian injury
Tekin, Yeşim Bayoğlu; Tümkaya, Levent; Mercantepe, Tolga; Topal, Zehra Suzan; Samancı, Tuğba Çelik; Yılmaz, Hülya Kılıç; Rakıcı, Sema Yılmaz; Topçu, Atilla (Wiley, 2024)Aim: This study focused on the anti-oxidant and anti-apoptotic effects of CoQ10 in ovaries exposed to pelvic radiation. Methods: Thirty-two female rats were randomly assigned into four groups. Group I (control group), Group ... -
Evaluation of the protective effects of amifostine and melatonin against cisplatin induced testis injury via oxidative stress and apoptosis in rats
Eren, Hüseyin; Mercantepe, Tolga; Tümkaya, Levent; Mercantepe, Filiz; Dil, Eyüp; Horsanali, Mustafa Ozan; Yılmaz, Adnan (Academic Press Inc Elsevier Science, 2020)..... -
Histopathological evaluation of the effects of dexmedetomidine against pituitary damage ınduced by X-ray irradiation
Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema (Taylor & Francis Ltd., 2022)Background: The present study, aimed to investigate the potential negative effects of x-ray radiation and the effects of the α2-adrenergic receptor agonist dexmedetomidine on the pituitary gland. Methods: Twenty-four ...