dc.contributor.author | Atak, Mehtap | |
dc.contributor.author | Sevim Nalkıran, Hatice | |
dc.contributor.author | Bostan, Mehmet | |
dc.contributor.author | Uydu, Huseyin Avni | |
dc.date.accessioned | 2024-02-05T12:21:22Z | |
dc.date.available | 2024-02-05T12:21:22Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Atak, M., Sevim Nalkiran, H., Bostan, M., & Uydu, H. A. (2023). The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease. Acta cardiologica, 1–8. Advance online publication. https://doi.org/10.1080/00015385.2023.2285534 | en_US |
dc.identifier.issn | 0001-5385 | |
dc.identifier.uri | https://doi.org/10.1080/00015385.2023.2285534 | |
dc.identifier.uri | https://hdl.handle.net/11436/8702 | |
dc.description.abstract | Background: Controversial effect of sortilin on lipoprotein metabolism in the development of atherosclerosis reveals the need for more extensive research Objectives: The aim of this study was to investigate the association between Sort1 gene expression and lipids, lipoprotein subfractions, and inflammation in CAD. Methods: The study population included 162 subjects with CAD and 49 healthy individuals. The Sort1 gene expression level was determined by qRT-PCR using Human Sortilin TaqMan Gene Expression Assays. Lipoprotein subclasses were analysed by the Lipoprint system. Serum levels of apolipoprotein and CRP were measured by autoanalyzer. Results: Sort1 gene expression and atherogenic subfraction (SdLDL) levels were significantly higher (p < 0.001) while atheroprotective subfraction (LbLDL) was lower in the subjects with CAD (p < 0.050). Also, increased Sort1 gene expression levels were observed in those with higher CRP values. Conclusions: Our findings reveal that the high Sort1 gene expression has a prominent linear relationship with both the atherogenic LDL phenotype and proinflammation, thereby might contribute to the occurrence of CAD | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd. | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | CAD | en_US |
dc.subject | Inflammation | en_US |
dc.subject | LDL subfraction | en_US |
dc.subject | Sort1 expression | en_US |
dc.title | The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Atak, Mehtap | |
dc.contributor.institutionauthor | Nalkıran, Hatice Sevim | |
dc.contributor.institutionauthor | Bostan, Mehmet | |
dc.identifier.doi | 10.1080/00015385.2023.2285534 | en_US |
dc.relation.journal | Acta Cardiologica | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |