Kurum Yazarı "Çiçek, Ayşegül Çopur" Fen Edebiyat Fakültesi İçin Listeleme
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Antimicrobial resistance patterns and integron carriage of escherichia coli isolates causing community-acquired infections in Turkey
Çiçek, Ayşegül Çopur; Özgümüş, Osman Birol; Saral, Ayşegül; Sandallı, Cemal (Korean Soc Laboratory Medicine, 2014)We aimed to observe antimiCrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections. Two hundred sixty-eight E. coli strains were obtained from outpatients with ... -
Antimicrobial susceptibility and molecular characterization of multidrug-resistant acinetobacter baumannii isolated in an university hospital
Direkel, Şahin; Çiçek, Ayşegül Çopur; Karagöz, Alper; Aydoğan Ejder, Nebahat; Oktay, Efdal; Delialioğlu, Nuran; Özgümüş, Osman Birol; Durmaz, Rıza (Ankara Microbiology Soc, 2016)Acinetobacter baumannii, an aerobic, non-motile, gram-negative bacterium is an important nosocomial pathogen which shows resistance to the most antibiotics. Carbapenems are the most commonly used antibiotics for the treatment ... -
Beta-lactamase genes in carbapenem resistance Acinetobacter baumannii isolates from a Turkish university hospital
Coşkun, Umut Safiye Say; Çalışkan, Emel; Çiçek, Ayşegül Çopur; Turumtay, Halbay; Sandallı, Cemal (J Infection Developing Countries, 2019)Introduction: the spread of Acinetobacter baumannii, resistant to most of the available antimicrobial agents, is a serious health problem. the high rate of carbapenem resistance among Acinetobacter baumannii isolates is ... -
Carriage of class 1 and 2 integrons in acinetobacter baumannii and pseudomonas aeruginosa isolated from clinical specimens and a novel gene cassette array: bla(OXA-11)-cmlA7
Mengeloğlu, Fırat Zafer; Çiçek, Ayşegül Çopur; Koçoğlu, Esra; Sandallı, Cemal; Budak, Emine Esra; Özgümüş, Osman Birol (Ankara Microbiology Soc, 2014)The dissemination of antibiotic resistance genes between bacteria leads to serious problems in the treatment of infectious diseases. It has been shown that resistance genes can also be carried by the integrons. There are ... -
Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing beta-lactamases in Pseudomonas aeruginosa in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; Bonnin, Remy A.; Ceylan, Ayşenur; Saral, Ayşegül; Nordmann, Patrice; Sandalli, Cemal (Elsevier Science Inc, 2014)Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ... -
Cloning, expression, and characterization of a novel CTP synthase gene from Anoxybacillus gonensis G2
Sandallı, Cemal; Saral, Ayşegül; Ülker, Serdar; Karaoğlu, Hakan; Beldüz, Ali Osman; Çiçek, Ayşegül Çopur (2014)The cytidine-5'-triphosphate (CTP) synthase (EC 6.4.3.2) gene (pyrG) was cloned and sequenced from the thermophilic bacterium Anoxybacillus gonensis G2 (Ago). The gene is 1590 bp in length and encodes a protein of 530 amino ... -
Comparison of verona integron-borne metallo-beta-lactamase (VIM) variants reveals differences in stability and inhibition profiles
Makena, Anne; Düzgün, Azer Özad; Brem, Jurgen; McDonough, Michael A.; Rydzik, Anna M.; Abboud, Martine I.; Saral, Ayşegül; Çiçek, Ayşegül Çopur; Sandallı, Cemal; Schofield, Christopher J. (Amer Soc Microbiology, 2016)Metallo-beta-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. the Verona integron-borne metallo-beta-lactamase ... -
Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey
Çiçek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Kayman, Tuba; ÇIzmecI, Zeynep; Balci, Pervin Özlem; Dal, Tuba; Fırat, Mehmet; Tosun, İsmail; Altıntop, Yasemin Ay; Çalışkan, Ahmet; Yazıcı, Yelda; Sandallı, Cemal (Elsevier, 2013)Objective: To investigate the antibiotic resistance genes inserted into class 1 and class 2 integrons in Acinetobacter baumannii (A. baumannii) isolates obtained from nine different cities in Turkey. Methods: A collection ... -
Determination of a novel integron-located variant (bla(OXA-320)) of class D beta-lactamase in Proteus mirabilis
Çiçek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Sandallı, Cemal (Wiley, 2014)Proteus mirabilis (P. mirabilis) is one of Gram-negative pathogens encountered in clinical specimens. A clinical isolate (TRP41) of P. mirabilis was isolated from a Turkish patient in Turkey. the isolate was identified ... -
Determination of the staphylococcal cassette chromosome in methicillin-resistant Staphylococcus aureus strains isolated from various clinical samples
Çiçek, Ayşegül Çopur; Dinç Patlak, Rukiye; Sandallı, Cemal; Mengeloglu, Zafer; Kostakoğlu, Uğur; Yıldız, İlknur Esen (Science & Innovation, Ltd, 2016)Aim - the present study aimed to detect mecA and staphylococcal cassette chromosome mec (SCCmec) types in methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from various clinical samples in two university ... -
Distribution of beta-lactamase genes among carbapenem-resistant klebsiella pneumoniae strains isolated from patients in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Sandallı, Cemal; Doymaz, Mehmet Ziya; Akkoyunlu, Yasemin; Saral, Ayşegül; Peleg, Anton Y.; Özgümüş, Osman Birol; Beriş, Fatih Şaban; Karaoğlu, Hakan; Çiçek, Ayşegül Çopur (Korean Soc Laboratory Medicine, 2015)Background: the emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the beta-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates ... -
Effect of mazEF, higBA and relBE toxin-antitoxin systems on antibiotic resistance in Pseudomonas aeruginosa and Staphylococcus isolates
Coşkun, Umut Safiye Say; Çiçek, Ayşegül Çopur; Kılınç, Çetin; Güçkan, Rıdvan; Dağcıoğlu, Yelda; Demir, Osman; Sandallı, Cemal (Med Coll Malawi, 2018)Background A toxin-antitoxin (TA) system is a set of two or more closely linked genes that are encoded as a poison and a corresponding antidote on a protein. in typical bacterial physiology, an antitoxin binds to a toxin ... -
Evaluation of the carbapenem inactivation method for detection of carbapenemase-producing gram-negative bacteria in comparison with the RAPIDEC CARBA NP
Aktaş, Elif; Malkoçoğlu, Gülşah; Otlu, Barış; Çiçek, Ayşegül Çopur; Kulah, Canan; Cömert, Füsun; Sandallı, Cemal; Gürsoy, Nafia Canan; Erdemir, Duygu; Bulut, Mehmet Emin (Mary Ann Liebert, Inc, 2017)Timely detection of carbapenemases by both phenotypic and genotypic methods is essential for developing strategies to control the spread of infections by carbapenem-resistant isolates and related morbidity and mortality. ... -
High prevalence of NDM metallo-β-lactamase among ESBL-producing Escherichia coli İsolates
Çetinkol, Yeliz; Sandallı, Cemal; Çalgın, Mustafa Kerem; Yıldırım, Arzu Altunçekiç; Akyıldız, Esma; Karaman, Esin; Çiçek, Ayşegül Çopur (Akademiai Kiado Zrt, 2017)Resistance to beta-lactams in Enterobacteriaceae has been increasing worldwide. This study aimed to determine the frequency of beta-lactamase genes and antibiotic resistance rates of 140 extended-spectrum beta-lactamase ... -
Kinetic characterization of GES-22 beta-lactamase harboring the M169L clinical mutation
Saral, Ayşegül; Leonard, David A.; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; June, Cynthia M.; Sandallı, Cemal (Japan Antibiotics Research Assoc, 2016)The class A p-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ... -
Nationwide study of Escherichia coli producing extended-spectrum beta-lactamases TEM, SHV and CTX-M in Turkey
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Düzgün, Azer Özad; Yaşar, Ekrem; Çizmeci, Zeynep; Balcı, Pervin Özlem; Sarı, Fatma; Fırat, Mehmet; Altıntop, Yasemin Ay; Ak, Sibel; Çalışkan, Ahmet; Yıldız, Nazan; Sancaktar, Metin; Budak, Emine Esra; Ertürk, Ayşe; Özgüm, Osman Birol; Sandallı, Cemal (Nature Publishing Group, 2013)Four hundred and forty extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), ... -
A Novel integron gene cassette harboring VIM-38 Metallo-beta-lactamase in a clinical pseudomonas aeruginosa isolate
Beriş, Fatih Şaban; Akyıldız, Esma; Düzgün, Azer Özad; Coşkun, Umut Safiye Say; Sandallı, Cemal; Çiçek, Ayşegül Çopur (Korean Soc Laboratory Medicine, 2016)Dear Editor, Multidrug resistance of Pseudomonas aeruginosa has been attributed to both intrinsic and acquired antibiotic-resistance mechanisms. Multidrug-resistant (MDR) P. aeruginosa isolates have become a serious ... -
OXA- and GES-type beta-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Iraz, Meryem; Ceylan, Ayşenur; Düzgün, Azer Özad; Peleg, Anton Y.; Sandallı, Cemal (Elsevier Sci Ltd, 2014)We determined the antibiotic susceptibility and genetic mechanisms of resistance in clinical strains of Acinetobacter baumannii from Istanbul, Turkey. A total of 101 clinical strains were collected between November 2011 ...