Yazar "Ceylan, Şule" için FEF, Biyoloji Bölümü Koleksiyonu listeleme
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Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus
Bektaş, Hakan; Ceylan, Şule; Demirbaş, Neslihan; Alpay-Karaoğlu, Şengül; Sökmen, Bahar Bilgin (Birkhauser Boston, 2013)2-[6-(Morpholin-4-yl)pyridin-3-ylamino]acetohydrazide (4) was obtained starting from 6-morpholin-4-ylpyridin-3-amine (2) via the formation of ester (3) and then converted to the corresponding Schiff bases (5, 6) with the ... -
Conventional and microwave irradiated synthesis, biological activity evaluation of highly substituted indole-triazole hybrids
Cebeci, Yıldız Uygun; Ceylan, Şule; Karaoğlu, Şengül Alpay (Elsevier, 2022)In the present study, a series of new indole-3-carbaldehyde embedded triazole derivatives have been synthesized. 4-{[(1E)-1H-indol-3-ylmethylidene]amino}-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (2) were converted to ... -
Conventional and microwave-assisted synthesis of novel 1,2,4-triazole derivatives containing tryptamine skeleton and evaluation of antimicrobial activity
Cebeci, Yıldız Uygun; Ceylan, Şule; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Bentham Science Publishing, 2021)1,2,4-Triazole-3-one (3) obtained from tryptamine was transformed to the corresponding carbox(thio)amides via several steps (6a-d). Their reaction with sodium hydroxide performed the 1,2,4triazole derivatives (7a-d). ... -
An efficient microwave-assisted synthesis of novel quinolone-triazole and conazole-triazole hybrid derivatives as antimicrobial and anticancer agents
Cebeci, Yıldız Uygun; Ceylan, Şule; Karaoğlu, Şengül Alpay; Altun, Muhammed (Wiley, 2022)1,2,4-Triazole-fluoroquinolone and 1,2,4-triazole-conazole hybrids are designed, synthesized, and investigated in vitro against a variety of common diseases. The structure of the newly synthesized compounds are characterized ... -
Microwave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeleton
Ceylan, Şule; Bayrak, Hacer; ÖZdemir, Serap Başoğlu; Uygun, Yıldız; Mermer, Arif; Demirbaş, Neslihan; Ülker, Serdar (Walter de Gruyter Gmbh, 2016)Carbothioamides 4a,b, obtained from nalidixic acid, were converted to the corresponding 1,3-thiazolidine derivatives 5a,b by cyclocondensation with 2-bromo-1-(4-chlorophenyl) ethanone. Treatment of 4a,b with base afforded ... -
Microwave-assisted synthesis of novel mannich base and conazole derivatives containing biologically active pharmacological groups
Cebeci, Yıldız Uygun; Ceylan, Şule; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Bentham Science Publishers, 2021)Background: The aim of this study was to synthesize new Mannich bases and conazol derivatives with biological activity by the microwave-assisted method. Introduction: 1,2,4-Triazole-3-one (3) acquired from tryptamine was ... -
Novel microwave assisted synthesis and antimicrobial activity of new quinolone-hybrids
Ceylan, Şule; Bayrak, Hacer; Özdemir, Serap Başoğlu; Uygun, Yıldız; Mermer, Arif; Demirbaş, Neslihan; Ülker, Serdar (Bentham Science Publ Ltd, 2016)Background: Carbo(thio)amid derivatives 4a, 4b were obtained starting from nalidixic acid in three steps. the acidic treatment of compound 4a generated the corresponding 1,3,4-oxadiazole (5), while the compound 4a gave ... -
Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties
Ceylan, Şule; Bektaş, Hakan; Bayrak, Hacer; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay; Ülker, Serdar (Wiley, 2013)4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the ... -
Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
Özdemir, Serap Başoğlu; Cebeci, Yıldız Uygun; Bayrak, Hacer; Mermer, Arif; Ceylan, Şule; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Walter de Gruyter Gmbh, 2017)The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. the synthesis of conazole analogs 10a-f ... -
Synthesis and antimicrobial, antiproliferative evaluation of novel quinolone and conazole analogues via conventional and microwave techniques
Ceylan, Şule; Cebeci, Yıldız Uygun; Karaoğlu, Şengül Alpay; Altun, Muhammed (Wiley, 2021)1,2,4-Triazole-3-one (3), acquired from cinnamaldehyde was converted to the corresponding carbox(thio)amides via several steps (6 a-c). Their reaction with sodium hydroxide gave the 1,2,4-triazole derivatives (7 a-c). ... -
Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities
Ceylan, Şule; Bayrak, Hacer; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Maik Nauka/Interperiodica/Springer, 2014)1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbothioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3- ...