dc.contributor.author | Demir, Kamile | |
dc.contributor.author | Uzun, Feyzahan | |
dc.date.accessioned | 2024-06-27T07:11:05Z | |
dc.date.available | 2024-06-27T07:11:05Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.citation | Demir, K., & Uzun, F. (2024). The impact of systemic isotretinoin treatment on the tear film, meibomian glands, and corneal endothelium. Cutaneous and ocular toxicology, 1–6. Advance online publication. https://doi.org/10.1080/15569527.2024.2366856 | en_US |
dc.identifier.issn | 1556-9527 | |
dc.identifier.uri | https://doi.org/10.1080/15569527.2024.2366856 | |
dc.identifier.uri | https://hdl.handle.net/11436/9139 | |
dc.description.abstract | Purpose: The study aims to investigate changes in tear function, meibomian glands and corneal endothelium in patients receiving systemic isotretinoin therapy. Materials and methods: This prospective study included 38 eyes from 38 patients (23 females and 15 males) treated with systemic isotretinoin (0.5–1 mg/kg/day) following the diagnosis of acne vulgaris. All patients underwent a comprehensive ophthalmologic examination at baseline, 1st month, and third month of treatment. Subjective complaints were assessed using the Ocular Surface Disease Index (OSDI). Tear functions were evaluated through non-invasive tear break up time (NIBUT) and Schirmer I test. Meibomian gland (MG) changes were examined using meibography. Corneal parameters, including endothelial cell density (ECD), coefficient of variation (CV), the number of cells with a hexagonal shape (6A), average cell area (AVG), and central corneal thickness (CCT) were assessed using non-contact specular microscopy. Results: The mean age of the patients was 19.29 ± 2.83 years. Ocular surface-related discomfort, measured with OSDI scores, significantly worsened at the third month measurements compared to the pre-treatment values (p < 0.001). In the 1st month of treatment, there was a significant decrease in NIBUT (p < 0.05). No statistically significant difference was found in the Schirmer test results at each visit. According to the 1st and third-month analysis, there was a significant increase in MG loss compared to the pre-treatment period (p < 0.001). ECD, CV, 6 A, AVG measurements at the first and third months showed a significant change compared to the pre-treatment values (p < 0.001). No significant difference was observed in the CCT measurements during the treatment. Conclusion: Systemic isotretinoin disrupted tear stability, caused MG loss, deterioration in corneal endothelium, and led to symptomatic complaints in patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd. | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Cornea | en_US |
dc.subject | Endothelium | en_US |
dc.subject | Isotretinoin | en_US |
dc.subject | Meibomian glands | en_US |
dc.subject | Tear | en_US |
dc.title | The impact of systemic isotretinoin treatment on the tear film, meibomian glands, and corneal endothelium | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Uzun, Feyzahan | |
dc.identifier.doi | 10.1080/15569527.2024.2366856 | en_US |
dc.relation.journal | Cutaneous and Ocular Toxicology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |