Başlık için Biyomühendislik Bölümü Koleksiyonu listeleme
Toplam kayıt 42, listelenen: 7-26
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Computational investigation of peptide binding stabilities of HLA-B*27 and HLA-B*44 alleles
(Elsevier Ltd, 2020)Major Histocompatibility Complex (MHC) is a cell surface glycoprotein that binds to foreign antigens and presents them to T lymphocyte cells on the surface of Antigen Presenting Cells (APCs) for appropriate immune recognition. ... -
Computational studies with flavonoids and terpenoids as BRPF1 inhibitors: in silico biological activity prediction, molecular docking, molecular dynamics simulations, MM/PBSA calculations
(Taylor & Francis Ltd., 2022)The BRPF1 protein is encoded by the BRPF1 gene. In addition, the BRPF1 gene is known to be upregulated in leukaemia. Recent studies have shown that it is also overexpressed in hepatocellular carcinoma (HCC) as well. ... -
Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents
(Elsevier, 2021)Building on our previous work that discovered chalcone as a promising pharmacophore for anticancer activity, we have various other chalcone derivatives and have synthesized a series of novel bischalcone to explore their ... -
Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents
(Taylor & Francis Ltd., 2022)The increase in the drug-resistant strains of Mycobacterium tuberculosis has led researchers to new drug targets. The development of new compounds that have effective inhibitory properties with the selective vital structure ... -
Desirable plant cell wall traits for higher-quality miscanthus lignocellulosic biomass
(Bmc, 2019)Background: Lignocellulosic biomass from dedicated energy crops such as Miscanthus spp. is an important tool to combat anthropogenic climate change. However, we still do not exactly understand the sources of cell wall ... -
Determination of exogenous adrenaline levels in patients undergoing cardiopulmonary resuscitation
(Amer Chemical Soc., 2023)Core-shell quantum dot ZnS/CdSe screen-printedelectrodeswere used to electrochemically measure human blood plasma levels ofexogenous adrenaline administered to cardiac arrest patients. Theelectrochemical behavior of ... -
Determination of novel SARS-CoV-2 inhibitors by combination of machine learning and molecular modeling methods
(Bentham Science, 2023)Introduction: Within the scope of the project, this study aimed to find novel inhibitors by combining computational methods. In order to design inhibitors, it was aimed to produce molecules similar to the RdRp inhibitor ... -
Development of all-solid-state antidiabetic drug metformin-selective microsensor and its electrochemical applications
(Wiley-V C H Verlag Gmbh, 2020)In this study, all-solid-state type potentiometric PVC membrane selective microsensor was developed for Metformin (MET) which is an antidiabetic drug active substance. Metformin-tetraphenylborate (MET-TPB) ion-pair was ... -
Development of MoS2 and Au nanoparticle including disposable CEA-based immuno-cytosensor platforms
(Springer, 2022)In this study, an electrochemical biosensor for determination of Carcinoembryonic antigen (CEA) biomarker using human breast ductal adenocarcinoma (MCF-7) and human ovarian adenocarcinoma (SK-OV-3) cancer cells was presented. ... -
Development of new cyclophilin d receptor inhibitors for the treatment of multiple sclerosis
(Ankara University, 2022)Objective: In this study, it was aimed to carry out computational studies for the development of new molecules for the inhibition of the cyclophilin D (CypD) receptor, which causes the disability of mitochondrial function ... -
Discovery of 5-(or 6)-benzoxazoles and oxazolo[4,5-b]pyridines as novel candidate antitumor agents targeting hTopo II alpha
(Elsevier, 2021)Discovery of novel anticancer drugs which have low toxicity and high activity is very significant area in anticancer drug research and development. One of the important targets for cancer treatment research is topoisomerase ... -
Drug repositioning approach for the treatment of ankylosing spondylitıs
(Ankara University, 2022)Objective: In this study, it was aimed to determine an FDA-approved molecule that inhibits the IL-17 receptor, which is an important target for the prevention of inflammation in Ankylosing Spondylitis (AS), using the ... -
Effects of extractive ammonia pretreatment on the ultrastructure and glycan composition of corn stover
(Frontiers Media Sa, 2019)Lignocellulosic biomass is highly recalcitrant and requires a pretreatment step to improve the enzyme accessibility and fermentable sugar yields during enzymatic hydrolysis. Our previous studies demonstrated the rearrangement ... -
Electrochemical evaluation of titanium (IV) oxide/polyacrylonitrile electrospun discharged battery coals as supercapacitor electrodes
(Wiley-V C H Verlag Gmbh, 2020)The TiO(2)nanoparticles are electrospun with polyacrylonitrile (PAN) polymer solution onto the discharged battery coal (DBC) electrode and the results are evaluated as a supercapacitor. the morphology and chemical composition ... -
An electrochemical immuno-cytosensor modified with nanofibers for the determination of a carcinoembryonic antigen
(Springer, 2024)In this study, La0.25Fe0.75FeO3 (PNp)perovskite nanoparticle was synthesized using the sol–gel method. PNp-coated polyacrylonitrile (PAN) nanofibers were prepared by electrospinning on the pencil graphite electrode (PGE) ... -
Electrochemical properties of coumarin 500 encapsulated in a liquid crystal guided electrospun fiber core and their supercapacitor application
(Amer Chemical Soc., 2022)Here, we first report a study on coumarin 500 and liquid crystal including polyacrylonitrile nanofibers in terms of synthesis, characterizations, and supercapacitor performances. SEM, POM, FTIR, and DSC measurements showed ... -
Evaluation of waste human hair as graphene oxide and examination of some characteristic properties
(TUBITAK, 2020)In this study, graphene oxide was synthesized from activated carbon obtained from waste hair for the first time using Modified Hummers method. the Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy ... -
Graphene-metallic nanocomposites as modifiers in electrochemical glucose biosensor transducers
(Iop Publishing Ltd, 2016)Graphene sheets and three different graphene-metallic nanocomposites including graphene-copper (graphene-Cu), graphene-nickel (graphene-Ni) and graphene-platinum (graphene-Pt) were prepared and characterized in the first ... -
Identification of novel inhibitors of the ABC transporter BmrA
(Academic Press Inc., 2020)The resistance of microbes to commonly used antibiotics has become a worldwide health problem. A major underlying mechanism of microbial antibiotic resistance is the export of drugs from bacterial cells. Drug efflux is ... -
In silico studies to develop new GSK3 beta inhibitors effective in the 's disease
(Bentham Science Publications, 2022)Background: Alzheimer's disease affects a large part of the world's population by prolonging the human life span and becoming an economic burden in the health system. Therefore, its treatment becomes more and more important ...