dc.contributor.author | Çalışkan, Nedime | |
dc.contributor.author | Menteşe, Emre | |
dc.contributor.author | Yılmaz, Fatih | |
dc.contributor.author | İlhan, Muhammed Süleyman | |
dc.date.accessioned | 2024-08-15T07:27:03Z | |
dc.date.available | 2024-08-15T07:27:03Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.citation | Çalişkan, N., Menteşe, E., Yilmaz, F., & Ilhan, M. S. (2024). Synthesis and Anticancer Activities of Amide-Bridged Coumarin–Quinazolinone Hybrid Compounds. Russian Journal of Organic Chemistry, 60(5), 918–926. https://doi.org/10.1134/s1070428024050142 | en_US |
dc.identifier.issn | 1070-4280 | |
dc.identifier.uri | https://doi.org/10.1134/s1070428024050142 | |
dc.identifier.uri | https://hdl.handle.net/11436/9256 | |
dc.description.abstract | Abstract: Some novel 3-aminoquinazolin-4(3H)-one derivatives were synthesized by the reaction of 2-aminobenzhydrazide and corresponding iminoester hydrochlorides and then reacted with coumarin-3-carbonyl chloride to obtain novel coumarin–quinazolinone hybrids. The synthesized hybrid compounds were screened for their anticancer activity against various human cancer and normal cell lines. N-{2-[(4-Bromo- and N-{2-[(3-bromo-phenyl)methyl]-4-oxoquinazolin-3(4H)-yl}-2-oxo-2H-1-benzopyran-3-carboxamides exhibited the highest cytotoxic effect on the PC-3 prostate cancer cell line: IC50 35.3 ± 0.6 and 36.8 ± 0.8 µg/L, respectively. N-{2-[(4-Fluoro-, N-{2-[(4-bromo-, and N-{2-[(3,4-dichloro-phenyl)methyl]-4-oxoquinazolin-3(4H)-yl}-2-oxo-2H-1-benzopyran-3-carboxamides showed the highest activity against the MCF-7 breast cancer cell line: IC50 48.5 ± 0.4, 44.8 ± 0.4 and 46.1 ± 0.5 µg/L, respectively. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anticancer | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | MCF-7 coumarin | en_US |
dc.subject | PC-3 | en_US |
dc.subject | Quinazolinone | en_US |
dc.title | Synthesis and anticancer activities of amide-bridged coumarin–quinazolinone hybrid compounds | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Çalışkan, Nedime | |
dc.contributor.institutionauthor | Menteşe, Emre | |
dc.contributor.institutionauthor | Yılmaz, Fatih | |
dc.identifier.doi | 10.1134/S1070428024050142 | en_US |
dc.identifier.volume | 60 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 918 | en_US |
dc.identifier.endpage | 926 | en_US |
dc.relation.journal | Russian Journal of Organic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |