dc.contributor.author | Sağır, Büşra | |
dc.contributor.author | Okutucu, Murat | |
dc.contributor.author | Arpa, Medeni | |
dc.contributor.author | Fındık, Hüseyin | |
dc.contributor.author | Uzun, Feyzahan | |
dc.contributor.author | Aslan, Mehmet Gökhan | |
dc.contributor.author | Şahin, Ünal | |
dc.contributor.author | Kaim, Muahmmet | |
dc.date.accessioned | 2024-08-20T07:46:02Z | |
dc.date.available | 2024-08-20T07:46:02Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.citation | Sagir, B., Okutucu, M., Arpa, M., Findik, H., Uzun, F., Gokhan Aslan, M., Şahin, Ü., & Kaim, M. (2024). Evaluation of Choroidal Thickness and Retinal Vessel Density with Serum HIF-1α and TNF-α Level in Patients with OSAS. Current eye research, 1–8. Advance online publication. https://doi.org/10.1080/02713683.2024.2386355 | en_US |
dc.identifier.issn | 0271-3683 | |
dc.identifier.issn | 1460-2202 | |
dc.identifier.uri | https://doi.org/10.1080/02713683.2024.2386355 | |
dc.identifier.uri | https://hdl.handle.net/11436/9284 | |
dc.description.abstract | Purpose: To reveal changes in choroidal thickness, retinal vessel density, and serum HIF-1α and TNF-α levels in obstructive sleep apnea syndrome (OSAS) and their correlation.
Methods: This prospective case-control study included 118 patients divided into mild-to-moderate OSAS (n = 40), severe OSAS (n = 39), and a control group (n = 39). Choroidal thickness was evaluated with OCT, vessel density with OCTA, AHI index with polysomnography, and serum HIF-1α and TNF-α levels were analyzed using the enzyme-linked immunosorbent assay.
Results: The serum HIF-1α values of the participants in the mild-moderate OSAS and severe OSAS groups were [893.25(406.7-2068) and 1027(453-2527), respectively], and were both significantly higher than the control group [(521.5(231.6-2741))] (p < 0.001). Serum TNF-α levels did not differ significantly between the groups (p = 0.051).). Subfoveal choroidal thickness (SFCT) values of the severe OSAS groups were significantly lower than the control group (p < 0.05). The superficial and deep capillary plexus vascular density (SVD and DVD) values of the severe OSAS group were lower than the control group (p < 0.05). Serum HIF-1α and TNF-α levels of all participants were negatively correlated with both their SVD values (p < 0.05, r: -0.220 and p < 0.05, r: -0.252, respectively) and their DVD values (p < 0.001, r: -0.324 and p = 0.001, r: -0.299, respectively).
Conclusions: Increased serum levels of inflammatory mediators (HIF-1α ve TNF-α) in OSAS cause a decrease in SFCT, SVD, and DVD, which is an indication of systemic vascular damage. Further research on developing treatment strategies to modulate TNF-α ve HIF-1α may help recede vascular morbidity in OSAS patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd. | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Choroidal thickness | en_US |
dc.subject | Hypoxia inducible factor 1 | en_US |
dc.subject | Obstructive sleep apnea syndrome | en_US |
dc.subject | Retinal vessel density | en_US |
dc.subject | Tumor necrosis factor alpha | en_US |
dc.title | Evaluation of choroidal thickness and retinal vessel density with serum HIF-1α and TNF-α level in patients with OSAS | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Sağır, Büşra | |
dc.contributor.institutionauthor | Okutucu, Murat | |
dc.contributor.institutionauthor | Arpa, Medeni | |
dc.contributor.institutionauthor | Fındık, Hüseyin | |
dc.contributor.institutionauthor | Uzun, Feyzahan | |
dc.contributor.institutionauthor | Aslan, Mehmet Gökhan | |
dc.contributor.institutionauthor | Şahin, Ünal | |
dc.contributor.institutionauthor | Kaim, Muhammet | |
dc.identifier.doi | 10.1080/02713683.2024.2386355 | en_US |
dc.relation.journal | Current Eye Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |