| dc.contributor.author | Keleş, Turgut | |
| dc.contributor.author | Seyhan, Gökçe | |
| dc.contributor.author | Bıyıklıoğlu, Zekeriya | |
| dc.contributor.author | Kolci, Kübra | |
| dc.contributor.author | Reis, Rengin | |
| dc.contributor.author | Barut, Burak | |
| dc.date.accessioned | 2024-09-09T12:47:36Z | |
| dc.date.available | 2024-09-09T12:47:36Z | |
| dc.date.issued | 2024 | en_US |
| dc.identifier.citation | eles, T., Seyhan, G., Biyiklioglu, Z., Kolci, K., Reis, R., & Barut, B. (2024). Dendritic, Water‐Soluble, and Nonaggregated Axially Substituted Silicon Phthalocyanine as Potential Endometrial Anticancer Agent. Applied Organometallic Chemistry. https://doi.org/10.1002/aoc.7699 | en_US |
| dc.identifier.issn | 0268-2605 | |
| dc.identifier.uri | https://doi.org/10.1002/aoc.7699 | |
| dc.identifier.uri | https://hdl.handle.net/11436/9303 | |
| dc.description.abstract | In this work, dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanines (EA-TD-Si and EA-TD-SiQ) were synthesized and characterized. Then, the supercoiled pBR322 plasmid DNA damage properties of EA-TD-Si and EA-TD-SiQ were examined using agarose gel electrophoresis without light irradiation. In addition, the cytotoxicity and phototoxicity of EA-TD-Si and EA-TD-SiQ on human endometrium adenocarcinoma (HEC-1B) cells were investigated using an MTT assay. The results indicated that EA-TD-SiQ had high photodamage properties via singlet oxygen depending on the light dose, while EA-TD-Si did not show any DNA damage without light. In addition, EA-TD-SiQ had higher phototoxic effects than EA-TD-Si on HEC-1B cells according to the MTT assay. These results revealed the potential of EA-TD-SiQ to be used as a PDT agent in endometrial cancer. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Wiley | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Endometrial cancer | en_US |
| dc.subject | Photodynamic therapy | en_US |
| dc.subject | Phthalocyanine | en_US |
| dc.subject | Silicon | en_US |
| dc.subject | Synthesis | en_US |
| dc.title | Dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanine as potential endometrial anticancer agent | en_US |
| dc.type | article | en_US |
| dc.contributor.department | RTEÜ | en_US |
| dc.contributor.institutionauthor | Keleş, Turgut | |
| dc.relation.journal | Applied Organometallic Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
