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Evolving clinical features of diabetic ketoacidosis: The impact of SGLT2 inhibitors

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Erişim

info:eu-repo/semantics/openAccess

Tarih

2024

Yazar

Genç, Selin
Evren, Bahri
Yiğit, Onur Selçuk
Şahin, İbrahim
Dayanan, Ramazan
Klisic, Aleksandra
Ertürk, Ayşe
Mercantepe, Filiz

Üst veri

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Künye

Genc, S., Evren, B., Yigit, O. S., Sahin, I., Dayanan, R., Klisic, A., Erturk, A., & Mercantepe, F. (2024). Evolving Clinical Features of Diabetic Ketoacidosis: The Impact of SGLT2 Inhibitors. Pharmaceuticals, 17(11), 1553. https://doi.org/10.3390/ph17111553

Özet

Background/Objectives: The antidiabetic effect of SGLT2 inhibitors (SGLT2-is) is based on their ability to increase glucose excretion through urine by inhibiting the kidney-resident SGLT2 protein. Euglycemic diabetic ketoacidosis (EuDKA) is an uncommon but potentially life-threatening adverse effect of these medications, which are notable for their antidiabetic, cardiovascular, and renal protective properties. This study aimed to clarify the impact of SGLT2-is on demographic, clinical, and biochemical characteristics in patients with DKA. Methods: A total of 51 individuals with a diagnosis of DKA were included in the trial; 19 of these patients were treated with SGLT2-is, while 32 were not. Patients diagnosed with DKA and treated with SGLT2-is were compared to those not treated with the medication in terms of clinical, biochemical, and laboratory characteristics. Results: The age of patients utilizing SGLT2-is was statistically considerably greater than that of non-users (p < 0.001). EuDKA was exclusively noted in the SGLT2-is cohort (p = 0.005). Urinary tract infections, vulvovaginitis, and genitourinary infections were substantially more prevalent among SGLT2-i users compared with non-users among both women and the overall patient group (p = 0.036, p = 0.001, p = 0.005, p = 0.003, respectively). Plasma glucose concentrations were significantly higher in SGLT2-i non-users (p = 0.006). Chloride (Cl−) concentrations were elevated among SGLT2-i users (p = 0.036). Conclusions: The study findings indicate that SGLT2 inhibitors may substantially influence age, serum chloride, EuDKA, and the occurrence of genitourinary infections in individuals with DKA.

Kaynak

Pharmaceuticals

Cilt

17

Sayı

11

Bağlantı

https://doi.org/10.3390/ph17111553
https://hdl.handle.net/11436/9831

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • Scopus İndeksli Yayınlar Koleksiyonu [5931]
  • TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu [1559]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]

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