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dc.contributor.authorKaraali, Nesrin Ünal
dc.date.accessioned2025-02-06T13:01:44Z
dc.date.available2025-02-06T13:01:44Z
dc.date.issued2025en_US
dc.identifier.citationKaraali, N. Ü. (2024). Design, Synthesis, and Urease Inhibition Activities of Some bis-Coumarin-perimidine Hybrid Compounds. Russian Journal of Organic Chemistry, 60(S1), S78—S84. https://doi.org/10.1134/s1070428024130116en_US
dc.identifier.issn1070-4280
dc.identifier.issn1608-3393
dc.identifier.urihttps://doi.org/10.1134/s1070428024130116
dc.identifier.urihttps://hdl.handle.net/11436/9994
dc.description.abstractA series of bis-coumarin-perimidine hybrids were designed and synthesized, and their structures were characterized by FT-IR, H-1 NMR, C-13 NMR, and elemental analyses spectral data. All newly synthesized compounds were screened for their urease activity. All synthesized compounds were found to be effective in urease enzyme inhibition. With IC50 values ranging from 0.022 +/- 0.50 to 0.098 +/- 0.10 mu M, the compounds exhibit more active inhibition than the standard thiourea (IC50 = 0.206 +/- 0.25 mu M). The compound N ',N ''-(2,2 '-(2,2 '-(2-oxo-1H-perimidine-1,3(2H)-diyl)bis(acetyl))bis(6-bromo-2-oxo-2H-chromene-3-carbohydrazide) has the best urease inhibition with IC50 = 0.022 +/- 0.50 mu M.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBis-coumarinen_US
dc.subjectPerimidineen_US
dc.subjectUreaseen_US
dc.subjectHybrid compounden_US
dc.titleDesign, synthesis, and urease inhibition activities of some bis-coumarin-perimidine hybrid compoundsen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Fen - Edebiyat Fakültesi, Kimya Bölümüen_US
dc.contributor.institutionauthorKaraali, Nesrin Ünal
dc.identifier.doi10.1134/S1070428024130116en_US
dc.identifier.volume60en_US
dc.identifier.issueSUPPL1en_US
dc.identifier.startpageS78en_US
dc.identifier.endpageS84en_US
dc.relation.journalRussian Journal of Organic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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