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dc.contributor.authorYıldız, İlknur Esen
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorBahçeci, İlkay
dc.contributor.authorArpa, Medeni
dc.contributor.authorBatçık, Şule
dc.contributor.authorYıldız, Yasin
dc.contributor.authorTümkaya, Levent
dc.date.accessioned2025-02-10T06:00:02Z
dc.date.available2025-02-10T06:00:02Z
dc.date.issued2025en_US
dc.identifier.citationYildiz, I. E., Mercantepe, T., Bahceci, I., Arpa, M., Batcik, S., Yildiz, Y., & Tumkaya, L. (2024). Investigation of the Effects of Fosfomycin in Kidney Damage Caused by CLP-Induced Sepsis. Life, 15(1), 2. https://doi.org/10.3390/life15010002en_US
dc.identifier.issn2075-1729
dc.identifier.urihttps://doi.org/10.3390/life15010002
dc.identifier.urihttps://hdl.handle.net/11436/9996
dc.description.abstractSepsis, a life-threatening condition characterized by dysregulated host responses to infection, often leads to multi-organ dysfunction, including kidney injury. Kidney damage in sepsis can have severe consequences and is associated with high mortality rates. This study aimed to investigate the potential therapeutic effects of fosfomycin (FOS), a broad-spectrum antibiotic with immunomodulatory properties, on kidney damage induced by cecal ligation and puncture (CLP)-induced sepsis in a rodent model. In total, 24 rats were randomly divided into three groups. Group 1 (n = 8), the healthy control group (C), received a single dose of 0.9% NaCl (saline) solution via an intraperitoneal (i.p.) route. To group 2 (n = 8), the CLP group, CLP-induced sepsis was applied without medication, and a single dose of 0.9% NaCl (saline) solution was applied i.p. before induction. To group 3 (n = 8), the CLP + FOS (500 mg/kg) group, a single dose of 500 mg/kg FOS was administered i.p. before sepsis induction. The effects of fosfomycin on kidney function, histopathological changes, inflammatory markers, oxidative stress, and apoptosis were assessed. In the fosfomycin-treated group, the histological analysis results demonstrated reduction in kidney tissue damage and inflammation. Additionally, fosfomycin attenuated the upregulation of pro-inflammatory cytokines and reduced oxidative stress markers in kidney tissue. Furthermore, fosfomycin treatment was associated with a decrease in apoptotic cell death in the kidney. These findings suggest that fosfomycin may have a protective effect on kidney damage caused by CLP-induced sepsis. The potential mechanisms underlying this protection include the modulation of inflammation, reduction of oxidative stress, and inhibition of apoptosis.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFosfomycinen_US
dc.subjectInflammationen_US
dc.subjectCLPen_US
dc.subjectKidneyen_US
dc.subjectRaten_US
dc.subjectSepsisen_US
dc.titleInvestigation of the effects of fosfomycin in kidney damage caused by CLP-induced sepsisen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorYıldız, İlknur Esen
dc.contributor.institutionauthorMercantepe, Tolga
dc.contributor.institutionauthorBahçeci, İlkay
dc.contributor.institutionauthorArpa, Medeni
dc.contributor.institutionauthorBatçık, Şule
dc.contributor.institutionauthorYıldız, Yasin
dc.identifier.doi10.3390/life15010002en_US
dc.identifier.volume15en_US
dc.identifier.issue1en_US
dc.identifier.startpage2en_US
dc.relation.journalLife-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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