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Controlled reperfusion for different durations in the treatment of ischemia-reperfusion injury of the rat ovary: evaluation of biochemical features, molecular gene expression, and histopathology

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Date

2015

Author

Yapca, Ömer Erkan
Kumbasar, Serkan
Salman, Süleyman
Yaralı, Oğuzhan
Şener, Ebru
Mammadov, Renad
Tekin, Yeşim Bayoğlu
Aksoy, Ayşenur
Albayrak, Abdulmecit
Çetin, Nihal

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Yapca, O. E., Kumbasar, S., Salman, S., Yarali, O., Sener, E., Mammadov, R., Tekin, Y. B., Aksoy, A., Albayrak, A., & Cetin, N. (2015). Controlled reperfusion for different durations in the treatment of ischemia-reperfusion injury of the rat ovary: evaluation of biochemical features, molecular gene expression, and histopathology. Canadian journal of physiology and pharmacology, 93(4), 269–274. https://doi.org/10.1139/cjpp-2014-0359

Abstract

High numbers of proinflammatory cells (PMNLs), which are carried by the blood to ischemic tissue during reperfusion, are considered responsible for inducing the inflammatory response that occurs in ischemia-reperfusion (I/R) injury. Our objective was to determine the controlled reperfusion (CR) interval duration (CRID) that would minimize the injury caused by the PMNLs that infiltrate ischemic tissue. Animal groups were divided into the following groups: Sham group, ovarian I/R group (OIR), and ovarian ischemia controlled-reperfusion groups OICR-1, OICR-2, OICR-3, OICR-4, OICR-5, OICR-6, which had their ovarian artery opened and then closed for 10, 8, 6, 4, 2, or 1 s, respectively. the results show that the COX-2 activity and the gene expression decreased while the COX-1 activity and the gene expression were found to be increased in parallel to the shortening of the period in CRID. From the histopathological examinations, the findings of hemorrhage, edema, congested vascular structures, degenerated cells, and migration and adhesion of PMNLs were scaled as follows: Sham group < OICR-6 < OICR-5 < OICR-4 < OICR-3 < OICR-2 < OICR-1. the results from the histopathological assessments were consistent with the molecular and biochemical findings. in conclusion, our findings suggest that increased COX-2 activity plays a role in I/R injury of the rat ovary, and that controlled reperfusion for 3, 2, or 1 s following 2 h of ischemia may attenuate the effects of I/R injury.

Source

Canadian Journal of Physiology and Pharmacology

Volume

93

Issue

4

URI

https://doi.org/10.1139/cjpp-2014-0359
https://hdl.handle.net/11436/2858

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  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • Scopus İndeksli Yayınlar Koleksiyonu [6032]
  • TF, Cerrahi Tıp Bilimleri Bölümü Koleksiyonu [1225]
  • TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu [1574]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



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