Topiramate has protective effect on renal injury
Citation
Cure, M.C., Cure, E., Tumkaya, L., Aydin, I., Kirbas, A., Efe, H., Sehitoglu, I., Yuce, S. (2015). Topiramate has protective effect on renal injury. Bratislava Medical Journal-Bratislavske Lekarske Listy, 116(4), 259-263. https://doi.org/10.4149/BLL_2015_050Abstract
Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-alpha) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. Methods: A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. After laparotomy, cross ligation of infrarenal abdominal aorta was applied for two hours in I/R groups which was followed by two hours of reperfusion. TPM (100 mg/kg/day) was orally administrated to animals in the I/R+TPM group for seven consecutive days before I/R. Results: the I/R group's TNF-a and interleukin-1 beta (IL-1(3) levels were significantly higher (1184.2 +/- 129.1 pg/mg protein; 413.1 +/- 28.8 pg/mg protein, respectively) than those of the control (907.8 +/- 113.0 pg/mg protein, p = 0.002; 374.7 +/- 23.7 pg/mg protein, p = 0.010, respectively) and I/R+TPM groups (999.5 +/- 115.2 pg/mg protein, p < 0.001; 377.9 +/- 30.9 pg/mg protein, p = 0.007, respectively). Conclusion: TPM may partially prevent renal damage in rats. the opening of new horizons of this kind of knowledge will help understand the complex challenge in the prevention of renal I/R damage (Tab. 1, Fig. 3, Ref. 42). Text in PDF www.elis.sk.
