Zoledronic acid aggravates kidney damage during ischemia reperfusion injury in rat
Erişim
info:eu-repo/semantics/closedAccessTarih
2015Yazar
Şehitoğlu, İbrahimTümkaya, Levent
Bedir, Recep
Kalkan, Yıldıray
Cüre, Medine Cumhur
Yücel, Ahmet Fikret
Zorba, Orhan Ünal
Yüce, Süleyman
Cüre, Erkan
Üst veri
Tüm öğe kaydını gösterKünye
Sehitoglu, I., Tumkaya, L., Bedir, R., Kalkan, Y., Cure, M. C., Yucel, A. F., Zorba, O. U., Yuce, S., & Cure, E. (2015). Zoledronic acid aggravates kidney damage during ischemia reperfusion injury in rat. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 34(1), 53–61. https://doi.org/10.1615/jenvironpatholtoxicoloncol.2015012424Özet
Introduction: Zoledronic acid (ZA), a bisphosphonate, increases the levels of cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-?), and reactive oxygen species (ROS) in subjects without cancer. Increased production of ROS, TNF-?, and IL-6 during ischemia and reperfusion (I/R) injury stimulates apoptosis that leads to renal injury. We aimed to investigate whether ZA treatment has a protective effect on renal tissues during I/R. Materials and Methods: Twenty-four Sprague-Dawley rats were used in this study, and they were subdivided randomly into three groups, each containing eight rats. Infrarenal abdominal aortic cross ligation was performed on the I/R group. After 2 h of ischemia, 2 h of reperfusion was applied. A single dose of 100 µg/kg ZA was administered intraperitoneally to the ZA group. I/R was performed after 48 h. Results: Whereas TNF-?, IL-6, and nitric oxide (NO) levels of the I/R group were higher than those of the control group, TNF-?, IL-6, and NO levels of the ZA group were higher than those of the I/R group [TNF-? (p=0.038), IL-6 (p=0.012), NO (p=0.002), and caspase-3 (p=0.037)] and the control group [TNF-? (p<0.001), IL-6 (p<0.001), NO (p<0.001), and caspase-3 (p<0.001)]. Whereas the carbonic anhydrase II (CA-II) level of the ZA group was lower than that of the control group (p=0.040), the CA-II level of the I/R group was higher than that of the control group (p=0.020). Conclusion: ZA may aggravate renal injury during I/R by increasing cytokine production and apoptosis. It may also increase renal injury and metabolic acidosis during I/R by suppressing CA-II enzyme activities. © 2015 by Begell House, Inc.
Kaynak
Journal of Environmental Pathology, Toxicology and OncologyCilt
34Sayı
1Bağlantı
https://doi.org/10.1615/JEnvironPatholToxicolOncol.2015012424https://hdl.handle.net/11436/4365