Total serum protein predicted mortality in patients with st-elevation myocardial ınfarction who underwent primary percutaneous coronary ıntervention: Results of 8-year follow-up
Citation
Yılmaz, A.S., Özyıldız, A.G., Kahraman, F. & Çetin, M. (2021). Total Serum Protein Predicted Mortality in Patients with St-elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention: Results of 8-Year Follow-up. E Journal of Cardiovascular Medicine, 9(2), 122-129. http://doi.org/10.32596/ejcm.galenos.2021-05-30Abstract
Objectives: ST-elevation myocardial infarction (STEMI) is globally one of the leading causes of mortality. Determining
modifiable mortality predictors to improve outcomes is critical. Total serum protein (TSP) is a composite indicator of
immunity, nutrition, and inflammation and it plays a vital role in biological pathways contributing to cardiovascular
diseases. TSP level has not been evaluated in patients with STEMI in the prediction of mortality previously.
Materials and Methods: The patients diagnosed with STEMI between March 2007 and May 2009 were included in the
study. TSP was obtained at admission to the hospital. Follow-up period of the study was 8 years and primary endpoint was
all-cause mortality. Participants were separated according to the presence of mortality and clinical parameters compared
between these two groups.
Results: The mean age of the total 99 patients was 61±12.4 years and 82 (82.8%) of them were male. While left ventricular
ejection fraction (LVEF) (p=0.001), serum albumin (p=0.014), and TSP (p<0.001) were lower, serum creatinine was higher (p=0.003) in the mortality group. Diabetes mellitus (p=0.007), increased age (p=0.027), LVEF (p=0.006), serum
creatinine level (p=0.023), and TSP (hazard ratio: 0.159, 95% confidence interval: 0.062-0.408, p<0.001) predicted
mortality independently.
Conclusion: TSP level predicted all-cause mortality independently in STEMI patients who underwent primary
percutaneous coronary intervention during 8-year follow-up