The association of new atherosclerosis markers with coronary collaterals in chronic total occlusion patients
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2022Author
Emlek, NadirÖzyıldız, Ali Gökhan
Ergül, Elif
Öğütveren, Muhammet Mürsel
Öztürk, Muhammet
Aydın, Cihan
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Emlek, N. Özyıldız, A.G., Ergül, E. Öğütveren, M.M., Öztürk, M. & Aydın, C. (2022). The association of new atherosclerosis markers with coronary collaterals in chronic total occlusion patients. Cardiovascular Surgery and Interventions, 9(3), 152-158. http://doi.org/10.5606/e-cvsi.2022.1368Abstract
Objectives: In the present study, we investigated the relationship between mentioned markers and chronic total occlusion collateral
development.
Patients and methods: A total of 243 patients (210 males, 33 females; mean age: 63.3±11.5; range, 51 to 76 years) who underwent
coronary angiography due to typical chest pain or myocardial ischemia detected in noninvasive stress tests and diagnosed with
≥1 major coronary artery occlusion between January and September 2020 were included in the cross-sectional observational study.
The angiographic collateral index was determined according to the Cohen-Rentrop classification. The patients were divided into two
groups according to the sufficiency of collateral development: the well-developed collaterals group (n=155) and the poor-developed
collaterals group (n=88).
Results: Statistically significant parameters in univariate logistic regression analysis were evaluated with multivariate (stepwise)
logistic regression analysis; as a result, presence of chronic total occlusion in left anterior descending artery (odds ratio [OR]=2.447;
95% confidence interval [CI], 1.160-5.162; p=0.019), total number of occlusions (OR=3.503; 95% CI, 1.445-8.494; p=0.006), left
ventricular ejection fraction (OR=1.056; 95% CI, 1.022-1.091; p=0.001), and the atherogenic index of plasma (OR=0.017; 95% CI,
1.022-1.091; p<0.001) were independently associated with well-developed collaterals. Although the triglyceride-glucose index
had statistical significance in the univariate analysis, it was not detected as an independent variable in the multivariate analysis.
The monocyte-lymphocyte ratio was not significant in the univariate analysis.
Conclusion: Of the new atherosclerosis markers, only the atherogenic index of plasma had an independent association with poor collateral
development