Microwave-assisted synthesis and investigation of urease inhibitory activities of some 1,2,4-triazol-3-ones containing salicyl and isatin moieties

Abstract

A series of 5-methyl-1,2,4-triazol-3-ones containing salicyl or isatin moieties were synthesized by using conventional and microwave heating techniques. In microwave heating, the compounds were synthesized by using both a monomod microwave reactor and domestic type microwave oven and their results were compared. The synthesized compounds were evaluated for their urease inhibitory activities. Among the synthesized compounds two isatin containing 1,2,4-triazol-3-one derivatives (IC50 = 0.5230 +/- 0.0318 and 0.4860 +/- 0.0317 mu M) showed higher activities than salicyl containing derivatives (IC50 = 0.5451 +/- 0.0315 and 0.7181 +/- 0.0345 mu M), while standard thiourea showed IC50= 0.5027 +/- 0.0293 mu M activity.