Yazar "İslamoğlu, Fatih" için listeleme
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Bazı yeni potansiyel biyolojik 4-(Arylidenamino)-2, 4-dihidro-3H- 1,2,4-Triazol-3-one bileşiklerinin mikrodalga- destekli sentezi ve pKa değerlerinin belirlenmesi
Bu çalışmada,sekiz yeni bazı potansiyel biyolojik aktif 4-(arilidenamino)-2,4-dihidro-1H-1,2,4-triazol-3-on bileşikleri mikrodalga yöntemi kullanılarak sentezlendi. Bu bileşiklerin yapıları farklı spektroskopik yöntemle ... -
Calculation of thermodynamic properties of the most important forty-seven different solvents to create an information data bank through semi-empirical quantum methods used in determination of theoretical pKa
İslamoğlu, Fatih; Erdoğan, Naciye (Natl Inst Science Communication-Niscair, 2020)In this study, we have calculated the thermodynamic properties, especially in determining the theoretical acidic properties and pKa values of organic compounds, as enthalpy (Delta H, kcal/mol), heat capacity (C, cal/Kmol), ... -
Correlation between phenolic compounds and antioxidant activity of Anzer tea (Thymus praecox Opiz subsp caucasicus var. caucasicus)
Turumtay, Emine Akyaz; İslamoğlu, Fatih; Çavuş, Derya; Şahin, Hüseyin; Turumtay, Halbay; Vanholme, Bartel (Elsevier Science Bv, 2014)Phenolic compounds of Thymus praecox Opiz subsp. caucasicus var. caucasicus were analyzed by high performance liquid chromatography equipped with an ultraviolet detector (HPLC-UV). Quercetin (co-eluting with luteolin) and ... -
Determination of biological activities and pka at drug active substance in some bisbenzimidazoles derivatives
İslamoğlu, Fatih; Erdoğan, Naciye; Menteşe, Emre (Raman Publ, 2016)Bisbenzimidazole derivatives have known different structures as drug active substance were evaluated for their biological activities such as antiviral and anti-tumor activities. in addition, acid dissociation constants ... -
Determination of protonation constants of some 3-alkyl(aryl)-4-(ptert- butyl(benzyl/benzyliden)amino)-4,5-dihydro-1H-1,2,4-triazole-5- one deriveatives with spectrophotometric method
The protonation constant values of different twelve 3-alkyl(aryl)-4-(p-t-butyl(benzyl/ benzyliden)amino)-4,5-dihydro-1H-1,2,4-triazole-5-one derivatives have been determined in ethanol %50 - water %50 mixtures by ... -
Determination of the pKa of Some triazole derivatives by the potentiometric method in dioxan-water mixtures
İslamoğlu, Fatih; Kahveci, Bahittin (2011)Stoichiometric protonation constants of some 3-alkyl(aryl)-4-(substituted benzylamino)-4,5-dihydro-1 H-1,2,4-triazol-5-ones derivatives were determined potentiometrically in 50% (v/v) dioxan-water mixtures at 25°C with an ... -
Determination of the pKa value of some 1,2,4-triazol derivatives in forty seven different solvents using semi-empirical quantum methods (PM7, PM6, PM6-DH2, RM1, PM3, AM1, and MNDO) by MOPAC computer program
İslamoğlu, Fatih; Erdoğan, Naciye; Hacıfazlıoğlu, Esra (Ovidius University Press, 2023)In this study, we calculated the enthalpy (?H, kcal/mol), entropy (?S, cal/K.mol) and free energy (?G, kcal/mol) thermodynamic values of each molecule for forty-seven different solvent media according to semi-empirical ... -
Determination of the protonation constants of some 4-(substituted benzylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones by the potentiometric method in ethanol-water mixtures
To gain more information about the effect of solvent on 4,5-dihydro-1H-1,2,4-triazol-5-ones, the stoichiometric protonation constants of thirteen triazoles in ethanol-water mixtures were determined at an ionic strength of ... -
Determination of the protonation constants of triazole derivatives in non-aqueous solvents
İslamoğlu, Fatih; Kahveci, Bahittin; Özil, Musa; Akyüz, Emine; Menteşe, Emre; Ekinci, Arife Pınar (2009)Different 17 triazole derivatives were titrated with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, rert-butyl alcohol, N,N-dimethylformamide and acetonitrile), using Potentiometric method. ... -
Evaluation of phenolic compounds in Tilia rubra Subsp. caucasica by HPLC-UV and HPLC-UV-MS/MS
Akyüz, Emine; Şahin, Hüseyin; İslamoğlu, Fatih; Kolaylı, Sevgi; Sandra, Pat (Taylor & Francis Ltd., 2014)Profile of phenolic compounds of Tilia rubra subsp. caucasica was measured by high performance liquid chromatography coupled with ultraviolet and tandem mass spectroscopy. Three different extraction methods (methonolic, ... -
In vitro antioxidant and acidic properties of novel 4-(5-Methyl- 24hienylmethyleneamino)-4,5-dihydro-1H-l,2,4-triazol-5one derivatives. Synthesis and characterization
Gürsoy Kol, O.; Yüksek, H.; İslamoğlu, Fatih (Syscom 18 SRL, 2012)In the present study 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-l,2,4-triazol-5- ones 2a-i reacted with 5-methylthiophene-2-carboxyaldehyde to afford the corresponding compounds 3a-i and the acetylation reactions of compounds ... -
Investigation of the usability of some triazole derivative compounds as drug active ingredients by ADME and molecular docking properties
İslamoğlu, Fatih; Hacıhasanoğlu, Ezgi (University Mohammed Premier Oujda, 2022)In this study, some important ADME parameters such as physicochemical properties, lipophilicity, water solubility, pharmacokinetics, medicinal chemistry and drug-likeness properties of ten triazole derivative compounds, ... -
Microwave assisted synthesis of some novel 2-(3-Chlorobenzyl)-1H-benzimidazole derivatives and determination of their antimicrobial activity and pKa values
Menteşe, Emre; Bekircan, Olcay; İslamoğlu, Fatih; Beriş, Fatih Şaban (Chiminform Data S A, 2015)In the present research, synthesis of new 2-(3-chlorobenzyl)-1H-benzimidazole derivatives bearing N-benzylidene, 1,2,4-triazole and N-acylhydrazone moiety is investigated. These novel compounds have been tested for their ... -
Microwave-assisted synthesis of novel 2,4-dihydro-5-[4-(trifluoromethyl) phenyl]-3h-1,2,4-triazol-3-ones and potentiometric determination of their pKa in nonaqueous solvents
Özil, Musa; İslamoğlu, Fatih; Menteşe, Emre; Kahveci, Bahittin (Wiley, 2010)The novel 4-amino- or 4-aryl-substituted 2,4-dihydro-5-[(4-trifluoromethyl) phenyl]-3H-1,2,4-triazol-3-ones 3a-3g were synthesized by reaction of N-(ethoxycarbonyl)-4-(trifluoromethyl)benzenehydrazonic acid ethyl ester (2) ... -
Microwave-assisted synthesis of some 1, 2, 4-triazol-3-ones and potentiometric determination of their pKa in amfiprotic and dipolar aprotic-water mixtures
İslamoğlu, Fatih; Menteşe, Emre; Özil, Musa; Turumtay, Emine Akyüz; Kahveci, Bahittin (0-Belirlenecek, 2013)The novel 5-alkyl(aryl)-4-(aryl)-2, 4-dihydro-3H-1, 2, 4-triazol-3-ones (1-12) were synthesized by reaction of (N?-ethoxycarbonyl)-4-alkyl(aryl)hydrazonic acid ethyl ester with primary amines by microwave irradiation. ... -
Microwave-assisted synthesis of some new benzylidenamino compounds and potentiometric determination of their pKa
A growing body of literature has shown the effectiveness of using microwaves in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new benzylidenamino compounds (4a-f) ... -
Novel phthalocyanines containing resorcinol azo dyes; synthesis, determination of pKa values, antioxidant, antibacterial and anticancer activity
Kantar, Cihan; Akal, Hayriye; Kaya, Bülent; İslamoğlu, Fatih; Türk, Mustafa; Şaşmaz, Selami (Elsevier Science Sa, 2015)There are many studies about effects on health of compounds having azo groups in literature. However, anticancer, antimicrobial and antioxidant properties of phthalocyanines containing azo dyes are unknown. Therefore, the ... -
Novel zinc(II)phthalocyanines bearing azo-containing schiff base: Determination of pKa values, absorption, emission, enzyme inhibition and photochemical properties
Kantar, Cihan; Mavi, Vildan; Baltaş, Nimet; İslamoğlu, Fatih; Şaşmaz, Selami (Elsevier Science Bv, 2016)Azo-containing schiff bases are well known and there are many studies about their various properties in literature. However, phthalocyanines bearing azo-containing schiff bases, their spectral, analytical and biological ... -
Rapid and efficient synthesis of a new series of 2-aryl-5-fluoro-6(4-phenylpiperazin-1-yl)-1H-benzimidazoles using microwave heating
Menteşe, Emre; Yılmaz, Fatih; İslamoğlu, Fatih; Kahveci, Bahittin (Sage Publications Ltd, 2015)A new series of 2-aryl-5-fluoro-6-(4-phenylpiperazin-1-yl)-1H-benzimidazoles was synthesised from the reaction of 4-fluoro-5-(4-phenylpiperazin-1-yl) benzene-1,2-diamine and iminoester hydrochlorides. 4-Fluoro-5-(4-pheny ... -
Studies on the protonation constants of some triazoles in ethanol-water mixtures
İslamoğlu, Fatih; Kahveci, Bahittin; Özil, Musa; Akyüz, Emine (Chemical Publishing Co., 2008)Several studies, involving the formation and investigation of biological activities of some triazoles derivatives. These derivatives have weak acidic properties. To gain more information about the effect of solvent on ...
