Yazar "Baltaş, Nimet" için listeleme
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a-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin
Kantar, Günay Kaya; Baltaş, Nimet; Şahin, Onur; Şaşmaz, Selami (Natl Inst Science Communication & Policy Research, 2023)Vanillin substituted novel zinc(II) azaphthalocyanines (ZnAzaPcs) have been synthesized and investigated for their & alpha;-glucosidase inhibition properties. The new compounds (1, 2, 1a and 2a) have been characterised ... -
Acethylcholinesterase inhibition, antibacterial and antioxidant properties of Diaryl oxalates
Kantar, Günay K.; Baltaş, Nimet; Beriş, Fatih Şaban; Şaşmaz, Selami (Bentham Science Publishers B.V., 2017)Objective: The main study was to synthesize the diaryl oxalates containing pharmacophore groups like eugenol and guaiacol moieties, investigate antioxidant, antibacterial and acethylcholinesterase inhibitory properties and ... -
Adsorption of Reactive Red 120 from aqueous solutions by cetylpyridinium-bentonite
Tabak, Ahmet; Baltaş, Nimet; Afşin, Beytullah; Emirik, Mustafa; Çağlar, Bülent; Eren, Erdal (Wiley, 2010)BACKGROUND: The removal of Reactive Red 120 (RR 120) from aqueous solutions using cetylpyridinium modified Resadiye bentonite (CP-bentonite) prepared by ion exchange was investigated with particular reference to the effects ... -
Bioactivity and enzyme inhibition properties of Stevia rebaudiana
Can, Zehra; Baltaş, Nimet (Bentham Science Publishers B.V., 2016)Objective: The main study was to evaluate the anti- inflammatory, anti-oxidant, and the gastro-protective properties of extracts of Stevia rebaudiana. In addition the purpose of the study was to investigate new, natural ... -
Biochemical properties of partially purified polyphenol oxidase and phenolic compounds of Prunus spinosa L. subsp dasyphylla as measured by HPLC-UV
Baltaş, Nimet; Pakyıldız, Semra; Can, Zehra; Dinçer, Barbaros; Kolaylı, Sevgi (Taylor & Francis Inc, 2017)Polyphenol oxidase (PPO) enzyme was extracted from Prunus spinosa L. subsp. dasyphylla plum, partially purified by acetone precipitation, and its biochemical properties were investigated. Different substrates (p-coumaric ... -
Bioevaluation of synthetic pyridones as dual inhibitors of alpha-amylase and alpha-glucosidase enzymes and potential antioxidants
Saleem, Faiza; Khan, Khalid Mohammed; Ullah, Nisar; Özil, Musa; Baltaş, Nimet; Hameed, Shehryar; Salar, Uzma; Wadood, Abdul; Rehman, Ashfaq Ur; Kumar, Mukesh; Taha, Muhammad; Haider, Syed Moazzam (Wiley, 2022)Herein, a library of novel pyridone derivatives 1-34 was designed, synthesized, and evaluated for alpha-amylase and alpha-glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1-34 were synthesized ... -
Chemical analysis and biological activity of the essential oils and extracts of two liverwort species growing in Turkey
Çelik, Gonca; Şahin, Hüseyin; Baltaş, Nimet; Batan, Nevzat; Karaoğlu, Şengül Alpay; Yaylı, Nurettin (University Belgrade, 2023)The aim of this study was to investigate the chemical composition of the essential oils (EOs) from two Diplophyllum species and to evaluate their bioactivity potential [antimicrobial, antioxidant, anti-urease, anti-xanthine ... -
Cholesterol forms and traditional lipid profile for projection of atherogenic dyslipidemia: lipoprotein subfractions and erythrocyte membrane cholesterol
Uydu, Hüseyin Avni; Bostan, Mehmet; Atak, Mehtap; Yılmaz, Adnan; Demir, Adem; Akcan, Buket; Sümer, Fatih; Baltaş, Nimet; Karadağ, Zakir; Uğurlu, Yavuz; Örem, Asım (Springer, 2014)Atherogenic dyslipidemia characterized by abnormal changes in plasma lipid profile such as low high-density lipoprotein (HDL) and increased triglyceride (TG) levels is strongly associated with atherosclerotic diseases. We ... -
Design, synthesis, molecular modeling, in vitro evaluation of novel piperidine-containing hydrazone derivatives as cholinesterase inhibitors
Tok, Fatih; Baltaş, Nimet; Abas, Burçin İrem; Tatar Yılmaz, Gizem; Kaya, Süleyman; Koçyiğit-Kaymakçıoğlu, Bedia; Çevik, Özge (Wiley, 2024)In an effort to develop new and effective therapeutic agents for Alzheimer's disease, a series of hydrazone derivatives bearing piperidine rings have been designed and synthesized. The chemical structures of the compounds ... -
Developing a scaffold for urease inhibition based on benzothiazoles: Synthesis, docking analysis, and therapeutic potential
Özil, Musa; Tuzcuoğlu, Özge; Emirik, Mustafa; Baltaş, Nimet (Wiley-V C Verlag GMBH, 2021)The synthesis, in silico molecular docking, and in vitro urease inhibition studies of a novel series of benzothiazole derivatives are reported. The title compounds in the two series, namely, 2-({5-[(benzothiazol-2-ylthio ... -
Diversely functionalized benzopyran scaffolds as potential lead candidates for treating Alzheimer's disease and diabetes
Naz, Fouzia; Seraj, Faiza; Taha, Muhammad; Özil, Musa; Salar, Uzma; Baltaş, Nimet; Ul-Haq, Zaheer; Tariq, Syeda Sumayya; Khan, Khalid Mohammed (Elsevier, 2024)The current study deals with the preparation of polyfunctional benzopyran derivatives 1–25, synthesized by the condensation of 2,4-dihydroxy benzophenone, substituted aldehydes, and malononitrile. These compounds were ... -
Effect of propolis in gastric disorders: inhibition studies on the growth of Helicobacter pylori and production of its urease
Baltaş, Nimet; Karaoğlu, Şengül Alpay; Tarakcı, Cemre; Kolaylı, Sevgi (Taylor & Francis Ltd, 2016)There is considerable interest in alternative approaches to inhibit Helicobacter pylori (H. pylori) and thus treat many stomach diseases. Propolis is a pharmaceutical mixture containing many natural bioactive substances. ... -
Efficient synthesis of 2-[(3,4-dichlorophenyl)methyl]-1h-benzimidazole derivatives, and their α-glucosidase inhibitory and antioxidant activities
Menteşe, Emre; Yılmaz, Fatih; Baltaş, Nimet (Bentham Science Publishers, 2020)In this work, some new 2-[(3,4-dichlorophenyl)methyl]-1H-benzimidazole derivatives containing different five-membered heterocycles like 1,3,4-oxadiazole, 1,3,4-triazole, and 1,3,4-thiadiazole moieties were designed and ... -
Hydrazinyl thiazole linked indenoquinoxaline hybrids: Potential leads to treat hyperglycemia and oxidative stress; Multistep synthesis, alpha-amylase, and antioxidant activities
Hameed, Shehryar; Khan, Khalid Mohammed; Salar, Uzma; Özil, Musa; Baltaş, Nimet; Saleem, Faiza; Qureshi, Urooj; Taha, Muhammad; Ul-Haq, Zaheer (Elsevier, 2022)A library of hydrazinyl thiazole-linked indenoquinoxaline hybrids 1-36 were synthesized via a multistep reaction scheme. All synthesized compounds were characterized by various spectroscopic techniques including EI-MS ... -
Imidazole-thiadiazole hybrids: A multitarget de novo drug design approach, in vitro evaluation, ADME/T, and in silico studies
Maqbool, Maryam; Solangi, Mehwish; Khan, Khalid M.; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Tariq, Syeda S.; Haq, Zaheer Ul; Taha, Muhammad (Wiley, 2024)A library of imidazole-thiadiazole compounds (1–24) was synthesized to explore their therapeutic applications. The compounds were subjected to meticulous in vitro evaluation against α-glucosidase, α-amylase, acetylcholinesterase ... -
Indenoquinoxaline-phenylacrylohydrazide hybrids as promising drug candidates for the treatment of type 2 diabetes: In vitro and in silico evaluation of enzyme inhibition and antioxidant activity
Hameed, Shehryar; Saleem, Faiza; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Ashraf, Sajda; Ul-Haq, Zaheer; Taha, Muhammad; Khan, Khalid Mohammed (Elsevier, 2024)Existing drugs that are being used to treat type-2 diabetes mellitus are associated with several side effects; thus, exploring potential drug candidates is still an utter need these days. Hybrids of indenoquinoxaline and ... -
Indole-pyridine carbonitriles: multicomponent reaction synthesis and bio-evaluation as potential hits against diabetes mellitus
Solangi, Mehwish; Khan, Khalid Mohammed; Ji, Xingyue; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Khan, Alamgir; Ul-Haq, Zaheer; Meghwar, Herchand; Taha, Muhammad (2023)Background: Diabetes mellitus is a significant health disorder; therefore, researchers should focus on discovering new drug candidates. Methods: A series of indole-pyridine carbonitrile derivatives, 1-34, was synthesized ... -
An inhibition potential on some metabolic enzymes (urease and xanthine oxidase), essential oil contents and antioxidant effect of Sideritis lanata L.
Saral, Özlem; Baltaş, Nimet; Karaköse, Mustafa (Springer, 2024)While people use the aerial parts of some Sideritis species as tea and sweetener, some species are used for medicinal purposes. In this study, anti-urease, anti-xanthine oxidase, and antioxidant activity of Sideritis lanata ... -
Inhibition properties of propolis extracts to some clinically important enzymes
Baltaş, Nimet; Yıldız, Oktay; Kolaylı, Sevgi (Taylor & Francis Ltd, 2016)The present study was conducted to envisage inhibition effects of propolis on the crucial enzymes, urease, xanthine oxidase (XO) and acetylcholinesterase (AChE). Some of the antioxidant properties of the propolis samples ... -
Investigation of a wild pear species (Pyrus elaeagnifolia subsp Elaeagnifolia Pallas) from Antalya, Turkey: polyphenol oxidase properties and anti-xanthine oxidase, anti-urease, and antioxidant activity
Baltaş, Nimet (Taylor & Francis Inc, 2017)Polyphenol oxidase properties and anti-xanthine oxidase, anti-urease, and antioxidant activity were investigated in Pyrus elaeagnifolia subsp. elaeagnifolia Pallas harvested from Antalya, Turkey. Optimum pH and temperature ...
