Yazar "Khan, Khalid Mohammed" için listeleme
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Bioevaluation of synthetic pyridones as dual inhibitors of alpha-amylase and alpha-glucosidase enzymes and potential antioxidants
Saleem, Faiza; Khan, Khalid Mohammed; Ullah, Nisar; Özil, Musa; Baltaş, Nimet; Hameed, Shehryar; Salar, Uzma; Wadood, Abdul; Rehman, Ashfaq Ur; Kumar, Mukesh; Taha, Muhammad; Haider, Syed Moazzam (Wiley, 2022)Herein, a library of novel pyridone derivatives 1-34 was designed, synthesized, and evaluated for alpha-amylase and alpha-glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1-34 were synthesized ... -
Diversely functionalized benzopyran scaffolds as potential lead candidates for treating Alzheimer's disease and diabetes
Naz, Fouzia; Seraj, Faiza; Taha, Muhammad; Özil, Musa; Salar, Uzma; Baltaş, Nimet; Ul-Haq, Zaheer; Tariq, Syeda Sumayya; Khan, Khalid Mohammed (Elsevier, 2024)The current study deals with the preparation of polyfunctional benzopyran derivatives 1–25, synthesized by the condensation of 2,4-dihydroxy benzophenone, substituted aldehydes, and malononitrile. These compounds were ... -
Hydrazinyl thiazole linked indenoquinoxaline hybrids: Potential leads to treat hyperglycemia and oxidative stress; Multistep synthesis, alpha-amylase, and antioxidant activities
Hameed, Shehryar; Khan, Khalid Mohammed; Salar, Uzma; Özil, Musa; Baltaş, Nimet; Saleem, Faiza; Qureshi, Urooj; Taha, Muhammad; Ul-Haq, Zaheer (Elsevier, 2022)A library of hydrazinyl thiazole-linked indenoquinoxaline hybrids 1-36 were synthesized via a multistep reaction scheme. All synthesized compounds were characterized by various spectroscopic techniques including EI-MS ... -
Indenoquinoxaline-phenylacrylohydrazide hybrids as promising drug candidates for the treatment of type 2 diabetes: In vitro and in silico evaluation of enzyme inhibition and antioxidant activity
Hameed, Shehryar; Saleem, Faiza; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Ashraf, Sajda; Ul-Haq, Zaheer; Taha, Muhammad; Khan, Khalid Mohammed (Elsevier, 2024)Existing drugs that are being used to treat type-2 diabetes mellitus are associated with several side effects; thus, exploring potential drug candidates is still an utter need these days. Hybrids of indenoquinoxaline and ... -
Indole-pyridine carbonitriles: multicomponent reaction synthesis and bio-evaluation as potential hits against diabetes mellitus
Solangi, Mehwish; Khan, Khalid Mohammed; Ji, Xingyue; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Khan, Alamgir; Ul-Haq, Zaheer; Meghwar, Herchand; Taha, Muhammad (2023)Background: Diabetes mellitus is a significant health disorder; therefore, researchers should focus on discovering new drug candidates. Methods: A series of indole-pyridine carbonitrile derivatives, 1-34, was synthesized ... -
Multicomponent diastereoselective synthesis of tetrahydropyridines as α-amylase and α-glucosidase enzymes inhibitors
Saleem, Faiza; Shamim, Fariha; Özil, Musa; Baltaş, Nimet; Salar, Uzma; Ashraf, Sajda; Ul-Haq, Zaheer; Taha, Muhammad; Solangi, Mehwish; Khan, Khalid Mohammed (2023)Background: Researchers seeking new drug candidates to treat diabetes mellitus have been exploring bioactive molecules found in nature, particularly tetrahydropyridines (THPs). Methods: A library of THPs (1–31) were ... -
Regioselective syntheses of 2-oxopyridine carbonitrile derivatives and evaluation for antihyperglycemic and antioxidant potential
Saleem, Faiza; Haider, Maham; Khan, Khalid Mohammed; Özil, Musa; Baltaş, Nimet; Ul-Haq, Zaheer; Qureshi, Urooj; Salar, Uzma; Taha, Muhammad; Hameed, Shehryar; Ullah, Nisar (Elsevier, 2023)A library of 2-oxopyridine carbonitriles 1-34 was synthesized by regioselective nucleophilic substitution reactions. In the first step, a one-pot multicomponent reaction yield pyridone intermediates. The resulting pyridone ... -
Synthesis of arylated tetrahydrobenzo[H]quinoline-3-carbonitrile derivatives as potential hits for treatment of diabetes
Seraj, Faiza; Naz, Fouzia; Özil, Musa; Baltaş, Nimet; Tariq, Syeda Sumayya; Ul-Haq, Zaheer; Salar, Uzma; Taha, Muhammad; Khan, Khalid Mohammed (Taylor & Francis Ltd., 2024)Aim: Quinoline scaffolds are serving as the core structure for numerous antifungal, analgesic, antipyretic, anti-inflammatory drugs as well as have also been investigated for their potential antidiabetic properties. Though ... -
Synthesis of benzimidazoles containing piperazine ring as potential therapeutic agents against diabetes mellitus and antioxidant activities
Özil, Musa; Khan, Khalid Mohammed; Baltaş, Nimet; Wadood, Abdul; Samad, Abdus; Kahveci, Bahittin (Elsevier, 2024)We synthesized a novel 6-(4-substitue-piperazin-1-yl)-2-aryl-1H-benzimidazole derivatives starting from 5-(4-substitue-piperazin-1-yl)-2-nitroaniline with different aldehydes. A quick "onepot" nitro reductive cyclization ...
