Yazar "Saral, Ayşegül" için listeleme
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Acinetobacter baumannii izolatlarında antibiyotik direnç genlerinin taranması, Blages-22 ve Blaoxa-66 varyantlarının moleküler karakterizasyonu
Saral, Ayşegül (Recep Tayyip Erdoğan Üniversitesi / Fen Bilimleri Enstitüsü / Biyoloji Anabilim Dalı, 2015)Bu doktora tezinde, 101 Acinetobacter baumannii klinik suşunda direncin genetik mekanizmaları çalışıldı. blaOXA-51, blaOXA-23, blaOXA-40 ve blaOXA-58 benzeri genlerin tespiti için multipleks PZR kullanıldı. ISAba1, blaIMP, ... -
Anoxybacillus gonensis G2T CTP sentetaz geninin klonlanması, ekspresyonu, saflaştırılması ve amonyak-bağımlı CTP sentetaz aktivitesinin karakterizasyonu
Saral, Ayşegül (Rize Üniversitesi / Fen Bilimleri Enstitüsü / Biyoloji Anabilim Dalı, 2011)Sitidin 5'-trifosfat sentetaz (CTPs) primidin metabolizmasında son basamağı katalizleyen enzimdir. CTPs, ATP tarafından aktifleştirilen UTP'ye amino grubunu aktararak CTP oluşumunu katalizler. Nükleotid biyosentezinin ... -
Antimicrobial resistance patterns and integron carriage of escherichia coli isolates causing community-acquired infections in Turkey
Çiçek, Ayşegül Çopur; Özgümüş, Osman Birol; Saral, Ayşegül; Sandallı, Cemal (Korean Soc Laboratory Medicine, 2014)We aimed to observe antimiCrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections. Two hundred sixty-eight E. coli strains were obtained from outpatients with ... -
Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing beta-lactamases in Pseudomonas aeruginosa in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; Bonnin, Remy A.; Ceylan, Ayşenur; Saral, Ayşegül; Nordmann, Patrice; Sandalli, Cemal (Elsevier Science Inc, 2014)Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ... -
Cloning, expression, and characterization of a novel CTP synthase gene from Anoxybacillus gonensis G2
Sandallı, Cemal; Saral, Ayşegül; Ülker, Serdar; Karaoğlu, Hakan; Beldüz, Ali Osman; Çiçek, Ayşegül Çopur (2014)The cytidine-5'-triphosphate (CTP) synthase (EC 6.4.3.2) gene (pyrG) was cloned and sequenced from the thermophilic bacterium Anoxybacillus gonensis G2 (Ago). The gene is 1590 bp in length and encodes a protein of 530 amino ... -
Comparison of verona integron-borne metallo-beta-lactamase (VIM) variants reveals differences in stability and inhibition profiles
Makena, Anne; Düzgün, Azer Özad; Brem, Jurgen; McDonough, Michael A.; Rydzik, Anna M.; Abboud, Martine I.; Saral, Ayşegül; Çiçek, Ayşegül Çopur; Sandallı, Cemal; Schofield, Christopher J. (Amer Soc Microbiology, 2016)Metallo-beta-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. the Verona integron-borne metallo-beta-lactamase ... -
Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey
Çiçek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Kayman, Tuba; ÇIzmecI, Zeynep; Balci, Pervin Özlem; Dal, Tuba; Fırat, Mehmet; Tosun, İsmail; Altıntop, Yasemin Ay; Çalışkan, Ahmet; Yazıcı, Yelda; Sandallı, Cemal (Elsevier, 2013)Objective: To investigate the antibiotic resistance genes inserted into class 1 and class 2 integrons in Acinetobacter baumannii (A. baumannii) isolates obtained from nine different cities in Turkey. Methods: A collection ... -
Determination of a novel integron-located variant (bla(OXA-320)) of class D beta-lactamase in Proteus mirabilis
Çiçek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Sandallı, Cemal (Wiley, 2014)Proteus mirabilis (P. mirabilis) is one of Gram-negative pathogens encountered in clinical specimens. A clinical isolate (TRP41) of P. mirabilis was isolated from a Turkish patient in Turkey. the isolate was identified ... -
Determination of antibiotic resistance genes and virulence factors in Escherichia coli isolated from Turkish patients with urinary tract infection
Düzgün, Azer Özad; Okumuş, Funda; Saral, Ayşegül; Çiçek, Ayşegül Çopur; Cinemre, Sedanur (Soc Brasileira Medicina Tropical, 2019)Introduction: Escherichia coli ranks among the most common sources of urinary tract infections (UTI). Methods: Between November 2015 and August 2016, 90 isolates of E coli were isolated from patients at Rize Education and ... -
Distribution of beta-lactamase genes among carbapenem-resistant klebsiella pneumoniae strains isolated from patients in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Sandallı, Cemal; Doymaz, Mehmet Ziya; Akkoyunlu, Yasemin; Saral, Ayşegül; Peleg, Anton Y.; Özgümüş, Osman Birol; Beriş, Fatih Şaban; Karaoğlu, Hakan; Çiçek, Ayşegül Çopur (Korean Soc Laboratory Medicine, 2015)Background: the emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the beta-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates ... -
First report of qnr and blaVIM-4-like producing clinical Alcaligenes faecalis isolated in Türkiye
Akyıldız, Esma; Saral, Ayşegül; Köse, Tuba; Arslan, Mikail; Beriş, Fatih Şaban; Özad Düzgün, Azer (Gümüşhane Üniversitesi, 2023)The study set out to look at the clinical strain of A. faecalis's antibiotic susceptibility pattern. Both biochemical and molecular approaches were used to identify A.faecalis. The VITEK compact system was used to analyze ... -
Investigation of class 1 integrons with antibiotic resistance genes in multidrug-resistant acinetobacter baumannii strains and determination of plant extract effects on multidrug-resistant isolates
Saral, Ayşegül; Cinemre, Sedanur; Okumuş, Funda; Akar, Zeynep; Çiçek, Ayşegül Çopur; Düzgün, Azer Özad (Soc Stiinte Farmaceutice Romania, 2021)This study aimed to investigate the presence of resistance genes in multidrug-resistant A. baumannii isolates as well as to determine the antibacterial activity of selected plant extracts against isolates. 41 strains were ... -
Kinetic characterization of GES-22 beta-lactamase harboring the M169L clinical mutation
Saral, Ayşegül; Leonard, David A.; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; June, Cynthia M.; Sandallı, Cemal (Japan Antibiotics Research Assoc, 2016)The class A p-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ... -
Nationwide study of Escherichia coli producing extended-spectrum beta-lactamases TEM, SHV and CTX-M in Turkey
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Düzgün, Azer Özad; Yaşar, Ekrem; Çizmeci, Zeynep; Balcı, Pervin Özlem; Sarı, Fatma; Fırat, Mehmet; Altıntop, Yasemin Ay; Ak, Sibel; Çalışkan, Ahmet; Yıldız, Nazan; Sancaktar, Metin; Budak, Emine Esra; Ertürk, Ayşe; Özgüm, Osman Birol; Sandallı, Cemal (Nature Publishing Group, 2013)Four hundred and forty extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), ... -
OXA- and GES-type beta-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital
Çiçek, Ayşegül Çopur; Saral, Ayşegül; Iraz, Meryem; Ceylan, Ayşenur; Düzgün, Azer Özad; Peleg, Anton Y.; Sandallı, Cemal (Elsevier Sci Ltd, 2014)We determined the antibiotic susceptibility and genetic mechanisms of resistance in clinical strains of Acinetobacter baumannii from Istanbul, Turkey. A total of 101 clinical strains were collected between November 2011 ... -
Trabzon Fatih Devlet Hastanesinden İzole edilen klinik Acinetobacter baumannii ve Pseudomonas aeruginosa suşlarında antibiyotik direnç genlerinin araştırılması
Akyıldız, Esma; Saral, Ayşegül; Köse, Tuba; Beriş, Fatih Şaban; Düzgün, Azer Özad (Gümüşhane Üniversitesi, 2023)Bu çalışmanın amacı Acinetobacter baumannii ve Pseudomonas aeruginosa izolatlarının antibiyotik duyarlılık profilini araştırmak ve bu izolatlarda direnç genlerinin varlığını belirlemektir. Direnç genlerinin tespiti PCR ...
