dc.contributor.author | Keleş, Mustafa | |
dc.contributor.author | Al, Behçet | |
dc.contributor.author | Gümüştekin, Kenan | |
dc.contributor.author | Demircan, Berna | |
dc.contributor.author | Özbey, İsa | |
dc.contributor.author | Akyüz, Mehmet | |
dc.contributor.author | Yılmaz, Adnan | |
dc.contributor.author | Demir, Elif | |
dc.contributor.author | Uyanık, Abdullah | |
dc.contributor.author | Zipyak, Tevfik | |
dc.contributor.author | Taysi, Seyithan | |
dc.date.accessioned | 2020-12-19T20:11:40Z | |
dc.date.available | 2020-12-19T20:11:40Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Keles, M., Al, B., Gumustekin, K., Demircan, B., Ozbey, I., Akyuz, M., Yilmaz, A., Demir, E., Uyanik, A., Ziypak, T., & Taysi, S. (2010). Antioxidative status and lipid peroxidation in kidney tissue of rats fed with vitamin B(6)-deficient diet. Renal failure, 32(5), 618–622. https://doi.org/10.3109/0886022X.2010.481737 | en_US |
dc.identifier.issn | 0886-022X | |
dc.identifier.uri | https://doi.org/10.3109/0886022X.2010.481737 | |
dc.identifier.uri | https://hdl.handle.net/11436/3768 | |
dc.description | PubMed: 20486846 | en_US |
dc.description.abstract | Introduction: The aim of this study was to evaluate lipid peroxidation (LP) and free radical scavenging enzyme activities in kidney tissue of vitamin B6-deficient rats. Material and Methods: The rats were divided into control and vitamin B6-deficient groups. After 4 weeks of feeding, animals in all groups were anesthetized by thiopental sodium (50 mgkg). Thoraces were opened, 2 mL blood samples were taken from aortas, then the rats were killed by cervical dislocation, and kidney tissues were removed. Biochemical measurements in kidney tissue were carried out using a spectrophotometer. Results: Total superoxide scavenger activity (TSSA), nonenzymatic superoxide scavenger activity (NSSA), superoxide dismutase (SOD) activities, and antioxidant potential (AOP) values in the vitamin B6-deficient group were significantly lower than those of the control group, whereas glutathione peroxidase (GSH-Px), glutathione reductase (GRD), glutathione-S-transferase (GST) activities, and malondialdehyde (MDA) level were significantly higher than those of the control group (p < 0.05). Discussion: The results show that vitamin B6 deficiency causes an attenuation in antioxidant defense system and an increase in oxidative stress in kidney tissue of rats. © Informa UK, Ltd. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antioxidant enzymes | en_US |
dc.subject | Antioxidant potential | en_US |
dc.subject | Lipid peroxidation | en_US |
dc.subject | Vitamin | en_US |
dc.subject | Vitamin B6 deficiency | en_US |
dc.title | Antioxidative status and lipid peroxidation in kidney tissue of rats fed with vitamin B6-deficient diet | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Yılmaz, Adnan | |
dc.identifier.doi | 10.3109/0886022X.2010.481737 | |
dc.identifier.volume | 32 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 618 | en_US |
dc.identifier.endpage | 622 | en_US |
dc.relation.journal | Renal Failure | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |