dc.contributor.author | Şehitoğlu, İbrahim | |
dc.contributor.author | Tümkaya, Levent | |
dc.contributor.author | Bedir, Recep | |
dc.contributor.author | Kalkan, Yıldıray | |
dc.contributor.author | Cüre, Medine Cumhur | |
dc.contributor.author | Yücel, Ahmet Fikret | |
dc.contributor.author | Zorba, Orhan Ünal | |
dc.contributor.author | Yüce, Süleyman | |
dc.contributor.author | Cüre, Erkan | |
dc.date.accessioned | 2020-12-19T20:17:17Z | |
dc.date.available | 2020-12-19T20:17:17Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Sehitoglu, I., Tumkaya, L., Bedir, R., Kalkan, Y., Cure, M. C., Yucel, A. F., Zorba, O. U., Yuce, S., & Cure, E. (2015). Zoledronic acid aggravates kidney damage during ischemia reperfusion injury in rat. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 34(1), 53–61. https://doi.org/10.1615/jenvironpatholtoxicoloncol.2015012424 | en_US |
dc.identifier.issn | 0731-8898 | |
dc.identifier.uri | https://doi.org/10.1615/JEnvironPatholToxicolOncol.2015012424 | |
dc.identifier.uri | https://hdl.handle.net/11436/4365 | |
dc.description | PubMed: 25746831 | en_US |
dc.description.abstract | Introduction: Zoledronic acid (ZA), a bisphosphonate, increases the levels of cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-?), and reactive oxygen species (ROS) in subjects without cancer. Increased production of ROS, TNF-?, and IL-6 during ischemia and reperfusion (I/R) injury stimulates apoptosis that leads to renal injury. We aimed to investigate whether ZA treatment has a protective effect on renal tissues during I/R. Materials and Methods: Twenty-four Sprague-Dawley rats were used in this study, and they were subdivided randomly into three groups, each containing eight rats. Infrarenal abdominal aortic cross ligation was performed on the I/R group. After 2 h of ischemia, 2 h of reperfusion was applied. A single dose of 100 µg/kg ZA was administered intraperitoneally to the ZA group. I/R was performed after 48 h. Results: Whereas TNF-?, IL-6, and nitric oxide (NO) levels of the I/R group were higher than those of the control group, TNF-?, IL-6, and NO levels of the ZA group were higher than those of the I/R group [TNF-? (p=0.038), IL-6 (p=0.012), NO (p=0.002), and caspase-3 (p=0.037)] and the control group [TNF-? (p<0.001), IL-6 (p<0.001), NO (p<0.001), and caspase-3 (p<0.001)]. Whereas the carbonic anhydrase II (CA-II) level of the ZA group was lower than that of the control group (p=0.040), the CA-II level of the I/R group was higher than that of the control group (p=0.020). Conclusion: ZA may aggravate renal injury during I/R by increasing cytokine production and apoptosis. It may also increase renal injury and metabolic acidosis during I/R by suppressing CA-II enzyme activities. © 2015 by Begell House, Inc. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Begell House Inc. | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Carbonic anhydrase II | en_US |
dc.subject | Interleukin-6 | en_US |
dc.subject | Ischemia/reperfusion | en_US |
dc.subject | Kidney | en_US |
dc.subject | Zoledronic acid | en_US |
dc.title | Zoledronic acid aggravates kidney damage during ischemia reperfusion injury in rat | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Şehitoğlu, İbrahim | |
dc.contributor.institutionauthor | Tümkaya, Levent | |
dc.contributor.institutionauthor | Bedir, Recep | |
dc.contributor.institutionauthor | Kalkan, Yıldıray | |
dc.contributor.institutionauthor | Cüre, Medine Cumhur | |
dc.contributor.institutionauthor | Yücel, Ahmet Fikret | |
dc.contributor.institutionauthor | Zorba, Orhan Ünal | |
dc.contributor.institutionauthor | Cüre, Erkan | |
dc.identifier.doi | 10.1615/JEnvironPatholToxicolOncol.2015012424 | |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 53 | en_US |
dc.identifier.endpage | 61 | en_US |
dc.relation.journal | Journal of Environmental Pathology, Toxicology and Oncology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |