Kurum Yazarı "Mercantepe, Tolga" Tıp Fakültesi İçin Listeleme
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Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Şahin, Zafer; Akyıldız, Kerimali; Karataş, Kader Semra; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar (Elsevier, 2023)Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin has many side ef-fects, including cognitive impairment. Agomelatine, a synthetic melatonin analogue, is an important antide-pressant. ... -
Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
Dil, Eyüp; Topçu, Atilla; Mercantepe, Tolga; Tümkaya, Levent; Akyıldız, Kerimali; Saral, Sinan; Yılmaz, Adnan (Springer, 2023)Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ... -
Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Akyıldız, Kerimali; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar; Yılmaz, Adnan (Elsevier, 2021)It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the ... -
Biochemical and pathological changes in the male rat kidney and bladder following exposure to continuous 900-MHz electromagnetic field on postnatal days 22-59
Türedi, Sibel; Kerimoğlu, Gökçen; Mercantepe, Tolga; Odacı, Ersan (Taylor & Francis Ltd, 2017)Purpose: To investigate the effect on male rat kidney and bladder tissues of exposure to 900-megahertz (MHz) electromagnetic field (EMF) applied on postnatal days 22-59, inclusive. Materials and methods: Twenty-four male ... -
Can prenatal exposure to a 900 MHz electromagnetic field affect the morphology of the spleen and thymus, and alter biomarkers of oxidative damage in 21-day-old male rats?
Hancı, Hatice; Türedi, Sibel; Topal, Zehra Suzan; Mercantepe, Tolga; Bozkurt, İlyas; Kaya, Haydar; Ersöz, Şafak; Ünal, Bünyamin; Odacı, Ersan (Taylor & Francis Ltd, 2015)We investigated the effects of a 900 Megahertz (MHz) electromagnetic field (EMF), applied during the prenatal period, on the spleen and thymus of 21-day-old male rat pups. Pregnant Sprague-Dawley rats were divided into ... -
The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway
Topçu, Atilla; Kostakoğlu, Uğur; Mercantepe, Tolga; Yılmaz, Hülya K.; Tümkaya, Levent; Uydu, Hüseyin Avni (Wiley, 2022)Mortality rates associated with myocardial dysfunction due to sepsis and septic shock are generally high across the world. The present study focused on the antioxidant and anti-inflammatory effects of perindopril (PER) for ... -
Celastrol restricts experimental periodontitis related alveolar bone loss by suppressing inflammatory cytokine response
Altın, Ahmet; Korkmaz, Meltem Zihni; Atak, Mehtap; Mercantepe, Tolga; Yılmaz, Hülya Kılıç (China Medical University, 2023)Introduction: Periodontitis is a common chronic inflammatory disease characterized by the destruction of the supporting structures of the teeth. The host defense mechanisms are responsible for inflamatuar and destructive ... -
Changes in testicular morphology and oxidative stress biomarkers in 60-day-old Sprague Dawley rats following exposure to continuous 900-MHz electromagnetic field for 1 h a day throughout adolescence
Hancı, Hatice; Kerimoğlu, Gökçen; Mercantepe, Tolga; Odacı, Ersan (Pergamon-Elsevier Science Ltd, 2018)The purpose of this study was to investigate the 60-day-old male rat testis following exposure to continuous 900-megahertz (MHz) electromagnetic field (EMF) throughout the adolescent period using histopathological and ... -
Clinical and histologic evaluation of partial achilles tendon ınjury repair with amniotic membrane in rats
Background: Adhesions after tendinopathy in individuals who perform physical work and those physically active in middle age are a challenging problem for orthopedic surgeons. We evaluated the effects of human-derivated ... -
Comparative analysis of epigallocatechin-3-gallate and TNF-alpha inhibitors in mitigating cisplatin-induced pancreatic damage through oxidative stress and apoptosis pathways
Çiftel, Enver; Mercantepe, Filiz; Mercantepe, Tolga; Akyıldız, Kerimali; Yılmaz, Adnan; Çiftel, Serpil (Springer, 2024)Oxidative stress and inflammation caused by cisplatin, which is frequently used in the treatment of many cancers, damage healthy tissues as well as cancer cells. In this study, we aimed to investigate the effect of ... -
Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage
Şafak, Gökhan; Çeliker, Metin; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema; Çınar, Seda; Yılmaz, Adnan; Terzi, Suat; Demir, Emine; Erdivanlı, Özlem Çelebi; Coşkun, Zerrin Özergin; Karakaş, Sibel; Birinci, Mehmet; Dursun, Engin (Springer, 2022)Radiotherapy can be employed as a therapeutic modality alone in the early stages of cancer and is used together with other treatments such as surgery and chemotherapy in more advanced stages. However, exposure to ionizing ... -
Comparison of linear versus macrocyclic gadolinium chelates in rat skeletal muscle
Balık, Mehmet Sabri; Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Şahin, Rıfat; Balık, Gülşah (2022)OBJECTIVE: We investigated the effects on skeletal muscle of gadolinium based linear and macrocyclic radiocontrast agents applied at experimental intervals using histopathological methods. METHODS: Thirty-two male ... -
Dexamethasone and concentrated growth factors on peripheral nerve injury: A clinic-relevant animal study
Kalyoncu, Alperen; Balaban, Emre; Mercantepe, Tolga; Tümkaya, Levent (Elsevier, 2024)Background: Mandibular nerve injury is a common clinical condition that affects clinicians’ management and patients’ quality of life. In the literature, there are various effective treatments available. The primary purpose ... -
Dexmedetomidine alleviates vacuolization and necrosis in tubular epithelial cells induced by aortic cross-clamping
Ergene, Şaban; Hemşinli, Doğuş; Karakişi, Sedat Ozan; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Verduci Publisher, 2023)OBJECTIVE: Acute kidney inju-ry (AKI) is one of the main causes of mortality in patients undergoing emergency surgery due to an abdominal aortic aneurysm. This study aimed to determine the potential nephroprotec-tive ... -
Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury
Hemşinli, Doğuş; Tümkaya, Levent; Ergene, Şaban; Karakişi, Sedat Ozan; Mercantepe, Tolga; Yılmaz, Adnan (Taylor & Francis Ltd., 2022)Objective Despite significant improvements in interventional vascular aneurysm repair procedures and intensive care patient management, there has been no significant decrease in mortality due to ruptured abdominal aortic ... -
Dexmedetomidine on the interplay of IL-6 and STAT3 pathways in adrenal gland damage-induced scalding burns in rats
Çiftel, Serpil; Mercantepe, Filiz; Mercantepe, Tolga; Çiftel, Enver; Klisic, Aleksandra (Springer, 2024)Scalding burns are a common form of thermal injury that often leads to systemic complications. Pro-inflammatory cytokines like interleukin-6 (IL-6) and the activation of signal transducer and activator of transcription 3 ... -
The effect of dexmedetomidine on liver injury secondary to lower extremity ischemia-reperfusion in a diabetic rat model
Kartal, Seyfi; Şen, Ahmet; Tümkaya, Levent; Erdivanlı, Başar; Mercantepe, Tolga; Yılmaz, Adnan (Taylor & Francis Ltd., 2021)Introduction: In this study, we aimed to evaluate the hepatic protective effects of dexmedetomidine in the lower extremity ischemia-reperfusion model in diabetic rats biochemically and histopathologically. Methods: Rats ... -
The effect of gadolinium-based contrast agents on rat testis
Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Turan, Gupse; Yılmaz, Adnan; Beyazal, Mehmet; Turan, Abdulkadir; İnecikli, Mehmet Fatih; Kösem, M. (Wiley, 2018)Previous studies have reported that repeated administrations of linear gadolinium-based contrast agents lead to their accumulation in the brain and other tissues in individuals with normal renal functions. the purpose of ... -
The effect of imatinib administered in the prenatal period on testis development in rats
Suzan, Zehra Topal; Tümkaya, Levent; Mercantepe, Tolga; Atak, Muhammed; Uydu, Hüseyin Avni (Sage Publications Ltd, 2021)Background: the purpose of this study was to examine the effects of exposure to imatinib in the prenatal period on testis development in rats. Methods: Although all the study groups received intraperitoneal imatinib on ... -
Effect of the prenatal electromagnetic field exposure on cochlear nucleus neurons and oligodendrocytes in rats
Tümkaya, Levent; Baş, Orhan; Mercantepe, Tolga; Çınar, Seda; Özgür, Abdulkadir; Yazıcı, Zihni Açar (Springer Heidelberg, 2022)Electromagnetic radiation from elecromagnetic field (EMF) sources has been an important health concern for a long time. The vast majority of this exposure is due to the widespread use of mobile phones, an important source ...