Güncel Gönderiler: Tıp Fakültesi
Toplam kayıt 2828, listelenen: 1-20
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Medical management pathways for Cushing's disease in pituitary tumors centers of excellence (PTCOEs)
(Springer, 2025)PurposeA recent update of consensus guidelines for the management of Cushing's disease (CD) included indications for medical therapy. However, there is limited evidence regarding their implementation in clinical practice. ... -
The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome
(BMC, 2025)BackgroundPlacental syndrome, mainly composed of preeclampsia and fetal growth restriction, has an impact on the health of mother and baby dyads. While impaired placentation is central to their pathophysiology, the underlying ... -
Role of coagulation factors in hepatocellular carcinoma: a literature review
(MDPI, 2025)Hepatocyte carcinoma (HCC) is a globally prevalent neoplasm with profound effects on morbidity and mortality rates. This review summarizes the complex interactions between coagulation abnormalities and the pathophysiological ... -
Evaluation of retinal changes in women with different phenotypes of polycystic ovary syndrome
(MDPI, 2025)Background: The aim of our study was to evaluate the retinal nerve fiber layer (RNFL) and macular and choroidal thicknesses in women with different phenotypes of polycystic ovary syndrome (PCOS), and compare these measurements ... -
Investigation of ITGB3 heterogeneity to overcome trastuzumab resistance in HER2-positive breast cancer
(MDPI, 2025)HER2-positive breast cancer has an aggressive tumour progression among breast cancers characterized by the overexpression of HER2. Trastuzumab is an FDA-approved drug and has significantly improved outcomes for patients; ... -
Identification and characterization of a novel rat MAVS variant modulating NFκB signaling
(MDPI, 2025)The innate immune response serves as the primary defense against viral infections, with the recognition of viral nucleic acids by pattern recognition receptors (PRRs) initiating antiviral responses. Mitochondrial ... -
Is punica granatum efficient against sepsis? A comparative study of amifostine versus pomegranate
(MDPI, 2025)Sepsis is a clinical condition causing tissue damage as a result of infection and an exaggerated immune response. Sepsis causes 11 million deaths annually, a third of which are associated with acute lung injury (ALI). Rapid ... -
Investigation of the effects of fosfomycin in kidney damage caused by CLP-induced sepsis
(MDPI, 2025)Sepsis, a life-threatening condition characterized by dysregulated host responses to infection, often leads to multi-organ dysfunction, including kidney injury. Kidney damage in sepsis can have severe consequences and is ... -
Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis
(BMC, 2025)Background To investigate the preventive efficacy of methylsulfonylmethane (MSM) on alveolar bone destruction in rats with periodontitis. Methods Twenty-four male Sprague-Dawley rats were randomly divided into three groups: ... -
Effects of 5 G mobile phone network electromagnetic field exposure on testicular endoplasmic reticulum stress and the protective role of coenzyme Q10
(Elsevier, 2025)Aim. Nowadays, the electromagnetic field (EMF) has become an issue of electromagnetic pollution . This study aimed to determine the effect of 5 G Fr1 frequency band EMF waves on endoplasmic reticulum (ER) stress in testicular ... -
A pilot study assessing left ventricle diastolic function in the parasternal long-axis view
(eScholarship, 2025)Introduction: Spectral Doppler echocardiography is used to evaluate diastolic dysfunction of the heart. However, it is difficult to assess diastolic function with this modality in emergency department (ED) settings. Based ... -
Notch and hedgehog signalling axis drive senescence in HER2-positive breast cancer resistant to trastuzumab
(Istanbul University Press, 2024)Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, ... -
Evaluation of the frequency and clinical features of comorbid adult separation anxiety disorder in patients with generalized anxiety disorder
(ANP Publishing, 2024)Objective: The aim of this study is to examine the frequency and clinical features of comorbid Adult Separation Anxiety Disorder (ASAD) in patients with Generalized Anxiety Disorder (GAD). Method: A total of 80 patients ... -
The impact of the trigger day progesterone, luteinizing hormone and their interaction on live birth rates in GnRH antagonist cycles
(Wiley, 2025)Aim: This study aims to assess the impacts of various trigger day progesterone (P4) and luteinizing hormone (LH) levels on live birth rates (LBRs) in fresh in vitro fertilization (IVF) cycles, considering their elevation ... -
CDC20 and CCNB1 overexpression as prognostic markers in bladder cancer
(MDPI, 2025)Background: Bladder cancer (BC) is one of the ten most common cancers worldwide, with a high recurrence rate and significant variation in clinical outcomes based on tumor grade and stage. This study aimed to investigate ... -
Does radioactive iodine treatment affect thyroid size and tracheal diameter?
(MDPI, 2025)Background/Objectives: There exist three principal treatment modalities employed in the management of hyperthyroidism attributable to excessive hormone secretion by the thyroid gland: antithyroid pharmacotherapy, surgical ... -
Mastectomy, HER2 receptor positivity, NPI, late stage and luminal B-type tumor as poor prognostic factors in geriatric patients with breast cancer
(MDPI, 2025)Background/Objectives: This study aims to explore the risk factors associated with poor survival outcomes in geriatric female patients with breast cancer. Methods: This study utilized data from the METABRIC database to ... -
Endoscopic butterfly cartilage myringoplasty: our long term results
(Taylor & Francis Ltd., 2025)Background: Myringoplasty is one of the treatments used for perforated tympanic membrane. Aim/objective: We aimed to evaluate the long-term anatomical and functional outcomes of patients who underwent endoscopic inlay ... -
Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study
(BMC, 2024)Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart of care for first- and second-line therapies in combination with endocrine therapy (ET) for HR+/HER2- metastatic breast ...
