Kurum Yazarı "Kalkan, Yıldıray" TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu İçin Listeleme
-
Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction
Cüre, Erkan; Kırbaş, Aynur; Tümkaya, Levent; Cüre, Medine Cumhur; Kalkan, Yıldıray; Yılmaz, Arif; Yüce, Süleyman (Wolters Kluwer Medknow Publications, 2015)Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor ... -
Protective effects of infliximab on lung injury induced by methotrexate
Kurt, Aysel; Tümkaya, Levent; Türüt, Hasan; Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Şehitoğlu, İbrahim; Acıpayam, Ahmet (Elsevier Espana Slu, 2015)Introduction: Methotrexate (MTX) is used to treat cancers, several forms of arthritis and other rheumatic conditions, although MIX may cause pulmonary toxicity related to the production of free oxygen radicals, various ... -
Protective effects of thymoquinone and alpha-tocopherol on the sciatic nerve and femoral muscle due to lower limb ischemia-reperfusion injury
Erkut, Adem; Cüre, Medine Cumhur; Kalkan, Yıldıray; Balık, Mehmet Sabri; Güvercin, Yılmaz; Yaprak, Esra; Yüce, Süleyman; Şehitoğlu, İbrahim; Cüre, Erkan (Verduci Publisher, 2016)OBJECTIVE: Thymoquinone (TQ) is an antioxidant and anti-apoptotic substance found in the Nigella sativa plant. Alpha-tocopherol (alpha-TP) is a potent antioxidant. We aimed to determine whether or not TQ and TP have a ... -
Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity
Mercantepe, Tolga; Kalkan, Yıldıray; Tümkaya, Levent; Şehitoğlu, İbrahim; Mercantepe, Filiz; Yıldırmış, Sermet (Wroclaw Medical Univ, 2018)Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas ... -
Reversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneys
Bostan, Habib; Kalkan, Yıldıray; Tomak, Yakup; Tümkaya, Levent; Altuner, Durdu; Yılmaz, Adnan; Erdivanlı, Başar; Bedir, Recep (Taylor & Francis, 2011)Background: This study investigated the effect of injection of rocuronium or sugammadex alone and rocuronium + sugammadex on urea, creatinine, electrolyte levels, and histopathological findings in rats. Methods: Thirty-six ... -
Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats
Cüre, Erkan; Cüre, Medine Cumhur; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İbrahim; Kırbaş, Aynur; Yılmaz, Arif; Yüce, Süleyman; Gökçe, Mehmet Fatih (Wolters Kluwer Medknow Publications, 2014)Background and Aim: Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes ... -
Topiramate has protective effect on renal injury
Cüre, Medine Cumhur; Cüre, Erkan; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İlkyaz; Kırbaş, Aynur; Efe, Hasan; Şehitoğlu, İbrahim; Yüce, Süleyman (Comenius Univ, 2015)Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-alpha) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. ... -
Yetişkin sıçanlarda testis hücreleri ve kalsinörin ımmunopozitifliği üzerine ketaminin etkileri: Bir ımmunohistokimyasal ve histopatolojik çalışma
Kalkan, Yıldıray; Tümkaya, Levent; Bostan, Habib; Tomak, Yakup; Altuner, Durdu; Baş, Orhan; Zorba, Orhan Ünal; Uzun, Hakkı (2012)Bu çalışmada, sıçanlara uygulanan uzun süreli ketaminin testis germ hücreleri ve kalsinörin immunopozitif hücreler üzerine etkilerinin araştırılması amaçlandı. Otuz adet, yetişkin Sprague-Dawley erkek sıçan her grupta 6’şar ... -
Zoledronic acid aggravates kidney damage during ischemia reperfusion injury in rat
Şehitoğlu, İbrahim; Tümkaya, Levent; Bedir, Recep; Kalkan, Yıldıray; Cüre, Medine Cumhur; Yücel, Ahmet Fikret; Zorba, Orhan Ünal; Yüce, Süleyman; Cüre, Erkan (Begell House Inc., 2015)Introduction: Zoledronic acid (ZA), a bisphosphonate, increases the levels of cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-?), and reactive oxygen species (ROS) in subjects without cancer. ...