Yazar "RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü" için TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu listeleme
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Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Şahin, Zafer; Akyıldız, Kerimali; Karataş, Kader Semra; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar (Elsevier, 2023)Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin has many side ef-fects, including cognitive impairment. Agomelatine, a synthetic melatonin analogue, is an important antide-pressant. ... -
Agomelatine reverses scopolamine-ınduced learning and memory impairment in adult rats
Saral, Sinan; Kaya, Ali Koray; Topçu, Atilla; Öztürk, Aykut; Sümer, Ayşegül; Pınarbaş, Esra (Sakarya Üniversitesi, 2021)Amaç: Agomelatin, melatonin reseptör (MT1 ve MT2) agonisti ve serotonin reseptör (5-HT2C) antagonisti olan antidepresan bir ilaçtır. Artan kanıtlar, agomelatinin nöroprotektif ve nöromodülatör etkiye sahip olduğunu ... -
Alkol bazlı el antiseptiğinin tolere ve kabul edilebilirliğinin değerlendirilmesi
Amaç: Kullanıcının kabulü ve iyi bir cilt toleransı alkol bazlı el antiseptiği seçiminde en önemli kriterlerinden biri ol arak kabul edilir. Yöntem : Bu çalışma Recep Tayyip Erdoğan Üniversitesi Tıp Fakültesi Rize Eğitim ... -
Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Akyıldız, Kerimali; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar; Yılmaz, Adnan (Elsevier, 2021)It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the ... -
Association of paraoxonase-1 L55M and Q192R polymorphisms with PCOS risk and potential risk factors for atherosclerosis
Nalkıran, Hatice Sevim; Şahin, Serap Baydur; Ayaz, Teslime; Nalkıran, İhsan; Güzel, Ali İrfan; Eldeş, Tuğba; Yıldız, Yasin (Future Medicine Ltd, 2019)Aim: To examine the PON1-L55M and-Q192R polymorphisms for polycystic ovary syndrome (PCOS) risk in relation with atherosclerosis risk markers. Methods: Blood samples were collected from 203 women (PCOS [n = 151], control ... -
Can dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat?
Çınar, Seda; Tümkaya, Levent; Mercantepe, Tolga; Saral, Sinan; Rakıcı, Sema; Yılmaz, Adnan; Topçu, Atilla; Şen, Ahmet; Karakaş, Sibel (Springer, 2021)Approximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, ... -
Cholesterol forms and traditional lipid profile for projection of atherogenic dyslipidemia: lipoprotein subfractions and erythrocyte membrane cholesterol
Uydu, Hüseyin Avni; Bostan, Mehmet; Atak, Mehtap; Yılmaz, Adnan; Demir, Adem; Akcan, Buket; Sümer, Fatih; Baltaş, Nimet; Karadağ, Zakir; Uğurlu, Yavuz; Örem, Asım (Springer, 2014)Atherogenic dyslipidemia characterized by abnormal changes in plasma lipid profile such as low high-density lipoprotein (HDL) and increased triglyceride (TG) levels is strongly associated with atherosclerotic diseases. We ... -
Chronic restraint stress impairs spatial memory while decreasing hippocampal BDNF levels in rats
Saral, Sinan; Sümer, Ayşegül; Kaya, Ali Koray; Öztürk, Aykut; Topçu, Atilla (İnönü Üniversitesi Tıp Fakültesi, 2022)Aim: This study investigated the potential role of chronic restraint stress (CRS) on spatial memory, recognition memory, brain-derived neurotrophic factor (BDNF) and acetylcholine (ACh) levels in young adult rats. Material ... -
A comparative investigation of the nephrotoxic effects of various antihypertensive drugs in rats: biochemical and histopathological analysis
Malkoç, İsmail; Altunkaynak, Konca; Turan, Mehmet İbrahim; Gürsan, Nesrin; Hacımüftüoğlu, Ahmet; Akçay, Fatih; Üçüncü, Yılmaz; Süleyman, Halis (Carbone Editore, 2014)Aims: Hypertension is known to cause potentially fatal kidney damage. However, it is unclear whether long-term use of antihypertensive drugs establishes any toxic effect on the kidney. This study investigate whether ... -
Comparison of a novel antigen detection test with reverse transcription polymerase chain reaction assay for laboratory diagnosis of SARS-CoV-2 infection
Cirit, Osman Sezen; Mutlu, Esvet; Sancak, Banu; Kocagöz, Tanıl; Can, Özge; Çiçek, Candan; Sayıner, Ayça Arzu; Appak, Özgür; Uyar, Neval Yurttutan; Külah, Canan; Çiçek, Ayşegül Çopur; Özgümüş, Osman Birol; Altıntop, Yasemin Ay; Saatçi, Esma; Karslıgil, Tekin; Zer, Yasemin; Özen, Nevgün Sepin; Çekin, Yeşim; Karahan, Zeynep Ceren; Evren, Ebru; Karakoç, Ayşe Esra; Orhan, Sultan Gülbahçe; Mutlu, Derya; Bozdemir, Tuğba; Çaycı, Yeliz Tanrıverdi; Çınar, Canberk; Taşbakan, Meltem; Mert, Merve; Çınar, Ece; Kutlusoy, Oya Özlem Eren; Kocagöz, Sesin; Ertürk, Ayşe; Çelik, İlhami; Mete, Ayşe Özlem; Eneyli, Müge Günalp; Akdemir, İrem; Karakök, Taliha; İnan, Dilara; Atilla, Aynur; Taflan, Şevket Onur; Yörük, Kağan Etka (Springer, 2022)Molecular diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse transcription polymerase chain reaction (RT-PCR) in respiratory specimens is considered the gold standard method. ... -
Comparison of DNA isolation methods from mammalian sperm cells and development of a new protocol
Nalkıran, Hatice Sevim; Nalkıran, İhsan; Rakıcı, Sema Yılmaz; Tümkaya, Levent; Güzel, Ali İrfan (Effect Publishing Agency ( EPA ), 2021)Sperm DNA tightly packed with protamines makes the DNA isolation procedure from sperm cells long and laborious. Cell lysis is also a challenging step because of the disulfide bonds-rich membranes of the sperm cells. In ... -
Comparison of inflammatory biomarkers for detection of coronary stenosis in patients with stable coronary artery disease
Uydu, Hüseyin Avni; Bostan, Mehmet; Yılmaz, A.; Demir, Adem; Atak, Mehtap; Şaturoğlu, Ömer; Temiz, A.; Çiçek, Yağız Anıl; Erdoğan, Turan; Çetin, Mustafa; Canga, Aranzazu Gonzalez (Verduci Publisher, 2013)BACKGROUND: the objective of the current study was to evaluate the role of various inflammatory biomarkers in detection of coronary stenosis in patients with stable coronary artery disease (CAD) and healthy people. METHODS: ... -
Correlation of suicidal thoughts and toxoplasmosis in patients with depression
Bahçeci, İlkay; Bahçeci, Bülent; Şentürk, Şenol; Yıldız, İlknur Esen; Yazıcı, Zİhni Açar (Cureus Inc., 2021)Objective We investigated the correlation between serum anti-Toxplasma gondii IgG and suicidal thoughts in depressive patients. Methods Depressive patients with (n = 100) and without (n = 100) suicidal thoughts ... -
Çeşitli klinik örneklerden izole edilen candida türlerinin tanımlanmasında kromojenik besiyerinin değerlendirilmesi
Amaç: Bu çalışmada çeşitli klinik örneklerden izole edilen mayaların tür düzeyinde tanımlanmasında konvansiyonel mikolojik yöntemler ile Kromojenik besiyeri (Oxoid Brill iance™ Candida agar, İngiltere) (KB) kullanılarak ... -
Çeşitli klinik örneklerden izole edilen Escherichia coli ve Klebsiella cinsi bakterilerin fosfomisin duyarlılığının araştırılması
Amaç: Escherichia coli (E. coli) ve Klebsiella cinsi bakteriler geniş spektrumlu beta laktamazları (GSBL) ihtiva etmesi nedeniyle mortalitesi yüksek hastane enfeksiyonlarının en önemli etkenlerindendir. Bu çalışmada E. ... -
Çeşitli klinik örneklerden izole edilen stenotrophomonasmaltophilia suşlarının dağılımı ve antimikrobiyal duyarlılıkları: 8 yıllık çalışma
Bahçeci, İlkay; Kostakoğlu, Uğur; Duran, Ömer Faruk; Yıldız, İlknur Esen; Dilek, Aziz Ramazan (2021)Amaç: Hastane enfeksiyonları ve buna bağlı mortalitenin artması çoklu ilaç direncine sahip fırsatçı patojenleri her zamankinden daha fazla gündeme getirmiştir. Bunlar arasında yer alan stenotrophomonas maltophilia önemi ... -
Determination of the staphylococcal cassette chromosome in methicillin-resistant Staphylococcus aureus strains isolated from various clinical samples
Çiçek, Ayşegül Çopur; Dinç Patlak, Rukiye; Sandallı, Cemal; Mengeloglu, Zafer; Kostakoğlu, Uğur; Yıldız, İlknur Esen (Science & Innovation, Ltd, 2016)Aim - the present study aimed to detect mecA and staphylococcal cassette chromosome mec (SCCmec) types in methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from various clinical samples in two university ... -
The different distribution of hepatitis C virus genotypes in Eastern Black Sea region of Turkey
Hepatitis C virus (HCV) has infected about 170-200 million people worldwide and HCV genotypes have been related with a particular geographic distribution. The information of genotypes in chronic hepatitis C is critical for ... -
Effect of infliximab on renal injury due to methotrexate in rat
Kırbaş, Aynur; Cüre, Medine Cumhur; Kalkan, Yıldıray; Cüre, Erkan; Tümkaya, Levent; Şahin, Osman Zikrullah; Yüce, Süleyman; Kızılkaya, Bayram; Pergel, Ahmet (Iranian Soc Nephrolgy, 2015)Introduction. Methotrexate, an antagonist of folic acid used in the treatment of many cancers and inflammatory diseases, is associated with side effects that limit its usage. Infliximab has been reported to have a protective ... -
The effect of rocuronium, sugammadex, and their combination on cardiac muscle and diaphragmatic skeletal muscle cells
Kalkan, Yıldıray; Bostan, Habib; Tümkaya, Levent; Tomak, Yakup; Bostan, Mehmet; Yılmaz, Adnan; Türüt, Hasan; Temiz, Ahmet; Yalçın, Alper; Turan, Alparslan (Springer Link, 2012)Purpose: Rocuronium has been associated with muscle weakness when administered in prolonged infusions. The effect of sugammadex and rocuronium together on muscle is unknown. In this study, we examined the effects of ...