Kurum Yazarı "Kalkan, Yıldıray" TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu İçin Listeleme
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Adalimumab ameliorates abdominal aorta cross clamping which induced liver injury in rats
Cüre, Erkan; Cüre, Medine Cumhur; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İbrahim; Kırbaş, Aynur; Yılmaz, Arif; Yüce, Süleyman; Yücel, Ahmet Fikret (Hindawi Ltd, 2014)The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. Thirty male Wistar-albino ... -
Biochemical and histopathological effects on the rat testis after exposure to electromagnetic field during fetal period
Şehitoğlu, İbrahim; Tümkaya, Levent; Kalkan, Yıldıray; Bedir, Recep; Cüre, Medine Cumhur; Zorba, Orhan Ünal; Cüre, Erkan; Yüce, Süleyman (Iniestares, S.A., 2015)OBJECTIVES: Electromagnetic radiation (ER) emitted from cell phones may exert a detrimental influence on human health and may affect the man reproductive system. We aimed to study the biological and morphological effects ... -
The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development
Bedir, Recep; Tümkaya, Levent; Şehitoğlu, İbrahim; Kalkan, Yıldıray; Yılmaz, Adnan; Şahin, Osman Zikrullah (Informa Healthcare, 2015)Background: the aim of this study was to investigate the effects of exposure to a 900-MHz electromagnetic field (EMF) produced by mobile phones on the renal development of prenatal rats. Histopathological changes and ... -
Effect of infliximab against cisplatin-induced nephrotoxicity
Cüre, Erkan; Kırbaş, Aynur; Tümkaya, Levent; Cüre, Medine Cumhur; Şahin, Osman Zikrullah; Kalkan, Yıldıray; Yüce, Süleyman; Altuner, Durdu (Saudi Med J, 2014)Objectives: To investigate whether infliximab (Ib), an inhibitor of tumor necrosis factor alpha (TNF-alpha), prevents cisplatin (Cis)-induced nephrotoxicity. Methods: the study was performed in the Department of Internal ... -
Effect of infliximab on renal injury due to methotrexate in rat
Kırbaş, Aynur; Cüre, Medine Cumhur; Kalkan, Yıldıray; Cüre, Erkan; Tümkaya, Levent; Şahin, Osman Zikrullah; Yüce, Süleyman; Kızılkaya, Bayram; Pergel, Ahmet (Iranian Soc Nephrolgy, 2015)Introduction. Methotrexate, an antagonist of folic acid used in the treatment of many cancers and inflammatory diseases, is associated with side effects that limit its usage. Infliximab has been reported to have a protective ... -
The effect of prenatal exposure to 1800 MHz electromagnetic field on calcineurin and bone development in rats
Erkut, Adem; Tümkaya, Levent; Balık, Mehmet Sabri; Kalkan, Yıldıray; Güvercin, Yılmaz; Yılmaz, Adnan; Yüce, Süleyman; Cüre, Erkan; Şehitoğlu, İbrahim (Acta Cirurgica Brasileira, 2016)PURPOSE: To investigated the effects of exposure to an 1800 MHz electromagnetic field (EMF) on bone development during the prenatal period in rats. METHODS: Pregnant rats in the experimental group were exposed to radiation ... -
The effect of rocuronium, sugammadex, and their combination on cardiac muscle and diaphragmatic skeletal muscle cells
Kalkan, Yıldıray; Bostan, Habib; Tümkaya, Levent; Tomak, Yakup; Bostan, Mehmet; Yılmaz, Adnan; Türüt, Hasan; Temiz, Ahmet; Yalçın, Alper; Turan, Alparslan (Springer Link, 2012)Purpose: Rocuronium has been associated with muscle weakness when administered in prolonged infusions. The effect of sugammadex and rocuronium together on muscle is unknown. In this study, we examined the effects of ... -
Effect of sugammadex on rocuronium induced changes in pancreatic mast cells
Kalkan, Yıldıray; Tümkaya, Levent; Bostan, Habib; Tomak, Yakup; Altuner, Durdu; Yılmaz, Adnan; Erdivanlı, Başar; Bedir, Recep; Yalçın, Alper; Turan, Alparslan (Sage Publications Inc, 2015)Mast cells play a vital role in hypersensitivity reactions. Rocuronium is known to cause mast cell mobilization, hypersensitivity, and pancreatitis. the aim of this study was to investigate the effects of sugammadex on ... -
The effects of infliximab on laminin, NF kappa B, and Anti-TNF expression through Its effect on ischemic liver tissue
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Rakıcı, Halil; Akdoğan, Elif (Hindawi Ltd, 2016)The aim of this study was to investigate the possible protective effects of infliximab on expression of laminin, anti-TNF, and NF kappa B in the rat hepatic cells after ischemia/reperfusion (I/R). A total of 30 male Wistar ... -
Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver
Tomak, Yakup; Yılmaz, Adnan; Bostan, Habib; Tümkaya, Levent; Altuner, Durdu; Kalkan, Yıldıray; Erdivablı, Başar (Wiley, 2012)We investigated the effect of rocuronium- and sugammadex-induced mast cell increase and degranulation in rat portal triads. Forty-two rats, in six groups, received either rocuronium 1 mg.kg -1; sugammadex 15 mg.kg -1; ... -
Hepatic effects of ketamine administration for 2 weeks in rats
Kalkan, Yıldıray; Tomak, Yakup; Altuner, Durdu; Tümkaya, Levent; Bostan, Habib; Yılmaz, Adnan; Ünal, D.; Kara, A.; Turan, A. (Sage Publishing, 2014)The aim of the present study was to investigate the long-term and high-dose application of ketamine on the liver by employing histologic and biochemical methods. A total of 30 male rats were randomly assigned to control ... -
Infliximab modulates cisplatin-induced hepatotoxicity in rats
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Kırbaş, Aynur; Tümkaya, Levent; Yılmaz, Arif; Türkyılmaz, Ayşegül Küçükali; Sehitoğlu, İbrahim; Yüce, Süleyman (Galenos Publ, 2016)Background: Cisplatin (Cis) is one of the most com-monly used antineoplastic drugs. It is used as chemo-therapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary ... -
Influence of infliximab pretreatment on ischemia/reperfusion injury in rat intestine
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Alacam, Hasan; Erdivanlı, Başar; Aydın, İbrahim (Via Medica, 2014)The Pringle maneuver is used in hepatic surgery to prevent blood loss but is associated with ischemia-reperfusion injury. To investigate the effect of infliximab on inflammation and apoptosis in rat intestinal mucosa during ... -
Is adalimumab protective in ischemia‐reperfusion injury in lung?
Kurt, Aysel; Tümkaya, Levent; Kalkan, Yıldıray; Türüt, Hasan; Cüre, Medine Cumhur; Cüre, Erkan; Şehitoğlu, İbrahim; Bilgin, Hacer; Usta, Mustafa (Mashhad University of Medical Sciences, 2015)Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I?R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor?alpha (TNF??) inhibitor agent. We aimed ... -
Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats
Aras, Adem Bozkurt; Güven, Mustafa; Akman, Tarık; Özkan, Adile; Şen, Halil Murat; Düz, Uğur; Kalkan, Yıldıray; Coşkun, Şilan; Coşar, Murat (Shenyang Editorial Dept Neural Regeneration Res, 2015)Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally ... -
A novel model approach for esophageal burns in rats: a comparison of three methods
Kalkan, Yıldıray; Tümkaya, Levent; Akdoğan, Remzi Adnan; Yücel, Ahmet Fikret; Tomak, Yakup; Şehitoğlu, İbrahim; Pergel, Ahmet; Kurt, Aysel (Sage Publications Inc, 2015)Background: Corrosive esophageal injury causes serious clinical problems. We aimed to create a new experimental esophageal burn model using a single catheter without a surgical procedure. Materials and methods: We conducted ... -
The protective effect of adalimumab on renal injury in a model of abdominal aorta cross-clamping
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Tümkaya, Levent; Aydın, İbrahim; Kırbaş, Aynur; Efe, Hasan; Kurt, Aysel; Yüce, Süleyman (Wroclaw Medical Univ, 2016)Background. Adalimumab (ADA) is a potent inhibitor of tumor necrosis factor (TNF-alpha). ADA treatment suppresses proinflammatory cytokines, leading to a decrease or inhibition of the inflammatory process. Objectives. the ... -
The protective effect of infliximab against carbon tetrachloride-induced acute lung injury
Kurt, Aysel; Tümkaya, Levent; Yüce, Süleyman; Türüt, Hasan; Cüre, Medine Cumhur; Şehitoğlu, İbrahim; Kalkan, Yıldıray; Pusuroğlu, Gökhan; Cüre, Erkan (Mashhad Univ Med Sciences, 2016)Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha). We aimed to investigate whether Ib has a protective effect on CCl4 ... -
Protective effect of infliximab against carbon tetrachloride-induced hepatotoxicity
Şehitoğlu, İbrahim; Tümkaya, Levent; Bedir, Recep; Özer, Ender; Cüre, Medine Cumhur; Yüce, Süleyman; Kalkan, Yıldıray; Cüre, Erkan (Begell House Inc, 2015)Carbon tetrachloride (CCl4), a solvent frequently used in industry, can cause acute liver failure and liver fibrosis. Infliximab (Ib), a potent tumor necrosis factor alpha blocker, has a protective effect on the liver. ... -
The protective effect of infliximab on cisplatin-induced intestinal tissue toxicity
Aydın, İbrahim; Kalkan, Yıldıray; Özer, Ezgi Demir; Yücel, Ahmet Fikret; Pergel, Ahmet; Cüre, Erkan; Cüre, Medine Cumhur; Şahin, Dursun Ali (Verduci Publisher, 2014)OBJECTIVE: Cisplatin (CP) is a popular chemotherapeutic agent. However, high doses of CP may lead to severe side effects to the gastrointestinal system. the aim of this study was to investigate the protective effects of ...